Mal-PEG2-CH2CH2COOtBu
Mal-PEG2-CH2CH2COOtBu Basic information
- Product Name:
- Mal-PEG2-CH2CH2COOtBu
- Synonyms:
-
- Mal-PEG2-C2-Boc
- Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- Mal-PEG-2-C2-Boc,PROTAC Linkers,Inhibitor,inhibit,Mal PEG2 C2 Boc,MalPEG2C2Boc
- Mal-PEG2-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- CAS:
- 1374666-31-5
- MF:
- C15H23NO6
- MW:
- 313.35
- Mol File:
- 1374666-31-5.mol
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Mal-PEG2-CH2CH2COOtBu Chemical Properties
- Boiling point:
- 428.7±30.0 °C(Predicted)
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- pka
- -2.34±0.20(Predicted)
- color
- Colorless to light yellow
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Mal-PEG2-CH2CH2COOtBu Usage And Synthesis
Description
Mal-PEG2-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Uses
Mal-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-PEG2-CH2CH2COOtBuSupplier
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
Amatek Scientific Co. Ltd.
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- 0512-56316828
- info@amateksci.com
Xi'an Confluore Biological Technology Co., Ltd.
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- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Shanghai Haohong Pharmaceutical Co., Ltd.
- Tel
- 400-8210725 4008210725
- malulu@leyan.com