PIVMECILLINAM HYDROCHLORIDE
PIVMECILLINAM HYDROCHLORIDE Basic information
- Product Name:
- PIVMECILLINAM HYDROCHLORIDE
- Synonyms:
-
- PIVMECILLINAM HYDROCHLORIDE
- MW:
- 0
- Mol File:
- Mol File
PIVMECILLINAM HYDROCHLORIDE Usage And Synthesis
Uses
Pivmecillinam is an orally active prodrug of Amdinocillin (A576300), an broad spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2.
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: avoid concomitant use with valproate.
Methotrexate: penicillins can reduce the excretion of
methotrexate (increased risk of toxicity).
Probenecid: reduces excretion of penicillins.
Metabolism
Pivmecillinam is rapidly hydrolysed to mecillinam which is the active drug, plus pivalic acid and formaldehyde. About 45% of a dose may be excreted in the urine as mecillinam, mainly within the first 6 hours. Mecillinam is partly excreted with bile, giving rise to biliary concentrations about 3 times the serum levels.