Basic information Safety Supplier Related

TOPOTECAN-D6

Basic information Safety Supplier Related

TOPOTECAN-D6 Basic information

Product Name:
TOPOTECAN-D6
Synonyms:
  • TOPOTECAN-D6
  • (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • SKF-104864A-d6
  • (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • Hycamtin-d6
  • NSC-609669-d6
  • (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • [2H6]-Topotecan
CAS:
1044904-10-0
MF:
C23H23N3O5
MW:
421.45
Product Categories:
  • Heterocycles
  • Isotope Labelled Compounds
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals
Mol File:
1044904-10-0.mol
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TOPOTECAN-D6 Chemical Properties

Melting point:
213-218°C (dec)
storage temp. 
-20°C Freezer
solubility 
aqueous acid: soluble; DMSO: slightly; Methanol: soluble
form 
A solid
Stability:
Hygroscopic
CAS DataBase Reference
1044904-10-0
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TOPOTECAN-D6 Usage And Synthesis

Description

Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

Chemical Properties

Light Yellow to Greenish Powder

Uses

Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic

Uses

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

TOPOTECAN-D6Supplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Email
sales@regentsciences.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
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TOPOTECAN-D6(1044904-10-0)Related Product Information