ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE Chemical Properties

Melting point:

36-38°C

Boiling point:

391.4±37.0 °C(Predicted)

Density 

1.602

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

-9.02±0.39(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xi

HS Code 

2933599590

ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE Usage And Synthesis

Uses

Ethyl 2,6-Dichloro-5-nitropyrimidine-4-carboxylate is a useful chemical compound for preparation of pyrimidinediamines as IgE and/or IgG receptor modulators.

Synthesis

Ethyl ethyl 2,6-dihydroxy-5-nitropyrimidine-4-carboxylate was dissolved in acetonitrile (50 mL), stirred at room temperature for 30 minutes, trichlorophosphorus was added, warmed to reflux, and the reaction was carried out for 30 minutes, and the progress of the reaction was detected by thin layer chromatography. At the end of the reaction, cooled to room temperature, poured into ice water, stirred, extracted with dichloromethane (50mL??3), the organic phase was washed with saturated sodium bicarbonate solution, decolorized by activated charcoal and dried with anhydrous sodium sulfate, filtered, concentrated and then added isopropanol (30mL), heated to dissolve, stirred, a white solid precipitated, left to stand for 2h, filtered, filter cake was dried to obtain the target compound 2,6-dichloro-5- Nitropyrimidine-4-carboxylic acid ethyl ester.

ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE(54368-61-5)Related Product Information

• Diphenhydramine
• Sulfadiazine
• Pyrimidine