MOFEBUTAZONE
MOFEBUTAZONE Basic information
- Product Name:
- MOFEBUTAZONE
- Synonyms:
-
- 2fdbp
- 2-phenyl-3,5-dihydroxy-4-butylpyrazolidine
- 4-butyl-1-phenyl-3,5-dioxopyrazolidine
- 4-butyl-1-phenyl-3,5-pyrazolidinedione
- 4-butyl-1-phenyl-5-pyrazolidinedione
- arcomonoltablets
- mobutazon
- mobuzon
- CAS:
- 2210-63-1
- MF:
- C13H16N2O2
- MW:
- 232.28
- EINECS:
- 218-641-1
- Mol File:
- 2210-63-1.mol
MOFEBUTAZONE Chemical Properties
- Melting point:
- 102-103°
- Boiling point:
- 374.44°C (rough estimate)
- Density
- 1.1099 (rough estimate)
- refractive index
- 1.6450 (estimate)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 5.22±0.10(Predicted)
- color
- White to Off-White
MOFEBUTAZONE Usage And Synthesis
Originator
Butaphen,Wiedenmann
Uses
Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.
Definition
ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.
Manufacturing Process
A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.
brand name
Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.
Therapeutic Function
Antirheumatic, Analgesic, Antiinflammatory
World Health Organization (WHO)
Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Clinical Use
Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).
MOFEBUTAZONESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 400-6206333 18521732826;
- market@aladdin-e.com
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Tel
- 4009903999 13395398332
- sales@xiyashiji.com
MOFEBUTAZONE(2210-63-1)Related Product Information
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- OXYPHENYL BUTAZONE
- pipebuzone
- Phenylbutazone
- MOFEBUTAZONE
- 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]
- Feclobuzone
- OXYPHENBUTAZONE HYDRATE
- KETOPHENYLBUTAZONE
- PHENYLBUTAZONE (DIPHENYL-D10)
- gamma-hydroxyphenylbutazone
- CLOFEZONE
- Cinnofuradione
- proxifezone
- TIMTEC-BB SBB006034
- Benzoic acid, 2-(acetyloxy)-, (4-(4,4-dimethyl-3-oxopentyl)-3,5-dioxo- 1,2-diphenyl-4-pyrazolidinyl)methyl ester
- 3,5-Pyrazolidinedione, 4-butyl-4-((4-chlorophenyl)(phenylimino)methyl) -1,2-diphenyl-
- Butaglionamide