Ethyl propionylacetate Chemical Properties

Melting point:

98 °C

Boiling point:

83-84 °C/12 mmHg (lit.)

Density 

1.012 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.422(lit.)

Flash point:

172 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Miscible with glacial acetic acid.

form 

Liquid

pka

10.58±0.46(Predicted)

Specific Gravity

1.01

color 

Clear colorless to pale yellow

BRN 

970270

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

InChIKey

UDRCONFHWYGWFI-UHFFFAOYSA-N

CAS DataBase Reference

4949-44-4(CAS DataBase Reference)

NIST Chemistry Reference

Ethyl propionylacetate(4949-44-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29183000

MSDS

• Language:English Provider:Ethyl 3-oxovalerate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl propionylacetate Usage And Synthesis

Chemical Properties

colourless liquid

Uses

Ethyl propionylacetate acts as a precursor used in the preparation of 1-ethyl- and 1-n-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid bearing one or two substituents on the benzene ring. Further, it is used to prepare 3-propionyl-2H-cyclohepta[b]furan-2-one.

Uses

Ethyl propionylacetate has been used in the synthesis of 1-ethyl- and 1-n-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid bearing one or two substituents on the benzene ring.

Uses

An intermediate of Rosuvastatin.

Synthesis Reference(s)

Synthesis, p. 829, 1978 DOI: 10.1055/s-1978-24903

General Description

Ethyl propionylacetate reacts with tropolone p-toluenesulfonate in the presence of sodium ethoxide to give 3-propionyl-2H-cyclohepta[b]furan-2-one.

Ethyl propionylacetate(4949-44-4)Related Product Information

• Methyl propiolate
• Methyl 3-oxovalerate
• Ethyl chloroacetate
• Ethyl cyanoacetate
• ISOXADIFEN-ETHYL
• Ethyl acetate
• Ethanol
• Ethylparaben
• Ethyl isobutyrylacetate
• Trinexapac-ethyl
• Propionyl bromide
• Ethyl phenylacetate
• Ethyl propiolate
• Ethyl acrylate
• L-Alanyl-L-Glutamine
• Ethyl malonyl chloride
• Pitavastatin Impurity 8
• 5-PyriMidinecarboxylic acid, 4-(4-fluorophenyl)-1,2-dihydro-6-(1-Methylethyl)-2-oxo-, Methyl ester