1-Methylpyrrolidine Chemical Properties

Melting point:

-90 °C

Boiling point:

76-80 °C (lit.)

Density 

0.800 g/mL at 20 °C (lit.)

vapor pressure 

100 hPa (20 °C)

refractive index 

n20/D 1.425

Flash point:

−7 °F

storage temp. 

Store below +30°C.

solubility 

213g/l

form 

Liquid

pka

10.32(at 25℃)

color 

Clear colorless

PH

11.3 (1g/l, H2O)

explosive limit

1.1-9.1%(V)

Water Solubility 

fully miscible

BRN 

102445

InChIKey

AVFZOVWCLRSYKC-UHFFFAOYSA-N

LogP

1.1 at 23℃

CAS DataBase Reference

120-94-5(CAS DataBase Reference)

NIST Chemistry Reference

Pyrrolidine, 1-methyl-(120-94-5)

EPA Substance Registry System

N-Methylpyrrolidine (120-94-5)

Safety Information

Hazard Codes 

F,C,N

Risk Statements 

11-22-34-51/53-35-20/22

Safety Statements 

16-26-36/37/39-45-61-29

RIDADR 

UN 2924 3/PG 2

WGK Germany 

2

RTECS 

UY1420500

Autoignition Temperature

170 °C DIN 51794

TSCA 

Yes

HS Code 

2933 99 80

HazardClass 

3

PackingGroup 

II

Toxicity

LD50 orally in Rabbit: 280 mg/kg

MSDS

• Language:English Provider:1-Methylpyrrolidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Methylpyrrolidine Usage And Synthesis

Chemical Properties

colorless transparent volatile liquid. Freely soluble in water, soluble in alcohol, ether and other organic solvents.

Uses

1-Methylpyrrolidine is a methylated pyrollidine and is involved as an essential part of the structure of cefipime. It is also an active component of cigarette smoke.

Preparation

n-methylpyrrolidine was successfully synthesized in an aqueous medium by using methylamine and 1,4-dibromobutane in the presence of catalyst k2co3 at a moderated temperature. here, n-methylpyrrolidine was firstly synthesized via the green chemistry process, in which both the water solvent and potassium carbonate catalyst were inexpensive and environmentally friendly. also, the reaction temperature was quite moderated at 90°C.
green organic synthesis of n-methylpyrrolidine

Hazard

Flammable, dangerous fire risk. Irritant toskin and eyes.

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by intraperitoneal and intravenous routes. This material is strongly alkaline. Liquid and vapors are corrosive to the skin, eyes, or mucous membranes. A very dangerous fire hazard; keep away from sparks, heat sources, and powerful oxidizers. Keep in closed containers. To fight fire, use alcohol foam. When heated to decomposition it emits highly toxic fumes of NOx.

Synthesis

1-Methylpyrrolidine is prepared by hydrogenation of N-Methylpyrrole over Adams' catalyst.

1-Methylpyrrolidine(120-94-5)Related Product Information

• Povidone iodine
• 2-Methylpyrrolidine, 97+%, typically 99%
• Pyrrolidine
• N-Vinyl-2-pyrrolidone
• Polyvinylpyrrolidone
• T 2588G
• CefepiMe interMediate (7-PIME)
• 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
• Cefepime EP Impurity F
• Cefepime Impurity A
• Cefepime EP Impurity B
• N-Methyl-2-pyrrolidone
• METHYL-2-PYRROLIDONE
• 1-Pyrrolidino-1-cyclopentene
• 1-Phenyl-2-pyrrolidinone
• 1-ETHYL-3-PYRROLIDINOL
• 1-Cyanopyrrolidine
• N-[2-(4-Bromophenoxy)ethyl]pyrrolidine