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ZPCK

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ZPCK Basic information

Product Name:
ZPCK
Synonyms:
  • SL-01
  • carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s
  • (S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate
  • N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E
  • z-l-phe chloromethyl ketone
  • (S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.
  • ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone
  • (3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone
CAS:
26049-94-5
MF:
C18H18ClNO3
MW:
331.79
EINECS:
247-432-8
Mol File:
26049-94-5.mol
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ZPCK Chemical Properties

Melting point:
107-108 °C(lit.)
Boiling point:
503.1±50.0 °C(Predicted)
Density 
1.1630 (rough estimate)
refractive index 
1.6470 (estimate)
storage temp. 
-20°C
pka
10.74±0.46(Predicted)
optical activity
[α]23/D +30°, c = 1 in chloroform
CAS DataBase Reference
26049-94-5
EPA Substance Registry System
Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5)
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Safety Information

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
HS Code 
29225000

MSDS

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ZPCK Usage And Synthesis

Chemical Properties

white powder

Uses

ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.

Uses

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.

ZPCKSupplier

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