ZPCK Chemical Properties

Melting point:

107-108 °C(lit.)

Boiling point:

503.1±50.0 °C(Predicted)

Density 

1.1630 (rough estimate)

refractive index 

1.6470 (estimate)

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).

pka

10.74±0.46(Predicted)

form 

solid

color 

White

optical activity

[α]23/D +30°, c = 1 in chloroform

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

CAS DataBase Reference

26049-94-5

EPA Substance Registry System

Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

HS Code 

29225000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

ZPCK Usage And Synthesis

Description

SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.

Chemical Properties

white powder

Uses

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.

Uses

Enzyme inhibitor.

Uses

ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.

References

1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450

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