4-PYRROLIDIN-1-YLANILINE Chemical Properties

Melting point:

51 °C

Boiling point:

180-185 °C(Press: 16 Torr)

Density 

1.109±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

7.20±0.40(Predicted)

Appearance

Brown to black Solid

Safety Information

HazardClass 

IRRITANT

HS Code 

2933998090

4-PYRROLIDIN-1-YLANILINE Usage And Synthesis

Synthesis

GENERAL PROCEDURE: The general method for the synthesis of 4-(pyrrolidin-1-yl)aniline from 1-(4-nitrophenyl)pyrrolidine is as follows: 1-(substituted)4-nitrophenyl derivatives IVa, b, e, f (0.01 mol) were dissolved in NH4OH (20 mL, 30%) and an aqueous solution of sodium conidiosulfite (7 g, 0.04 mol) was quickly added (30 mL). The reaction mixture was refluxed for 15 min. After completion of the reaction, the mixture was cooled and the crude product was obtained by filtration. The crude product was washed and crystallized from dichloromethane to give the target compounds Va, b, e, f. Among them, 4-(pyrrolidin-1-yl)aniline Vb was obtained in 80% yield as a yellow oily substance (in agreement with the literature report) [66].

References

[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 7, p. 1863 - 1873
[2] Bioorganic Chemistry, 2014, vol. 57, p. 65 - 82
[3] Advanced Synthesis and Catalysis, 2018, vol. 360, # 11, p. 2131 - 2137
[4] Patent: US2005/49286, 2005, A1
[5] Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 1,151

4-PYRROLIDIN-1-YLANILINE(2632-65-7)Related Product Information

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• 2-PYRROLIDIN-1-YLANILINE 97,2-Pyrrolidin-1-ylaniline 97%
• 3-PYRROLIDIN-1-YLANILINE
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• DNP-PRO-LEU-GLY-CYS(ME)-HIS-ALA-D-ARG-NH2
• N-2-4-DNP-HYDROXY-L-PROLINE CRYSTALLINE
• (S)-(-)-1-(4-NITROPHENYL)-2-PYRROLIDINE&
• 2,4-DINITROPHENYL-L-PROLYL-L-LEUCYLGLYCYL-L-ISOLEUCYL-L-ALANYLGLYCYL-L-ARGININE AMIDE
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• 4-PYRROLIDIN-1-YLANILINE
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• DNP-PRO-GLN-GLY-OH
• DNP-PRO-LEU-GLY-LEU-TRP-ALA-D-ARG-NH2
• DNP-L -PROLYL-L -LEUCYLGLYCINE
• 3-Chloro-2-pyrrolidin-1-ylaniline