4-Chloro-2-fluorobenzyl alcohol Chemical Properties

Boiling point:

227.6±25.0 °C(Predicted)

Density 

1.344±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.68±0.10(Predicted)

Appearance

White to off-white Solid-Liquid Mixture

CAS DataBase Reference

56456-49-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2906290090

4-Chloro-2-fluorobenzyl alcohol Usage And Synthesis

Synthesis

A solution of 4-chloro-2-fluorobenzoic acid (300mg) in THF (15m1) was added at 0CLiAIH4 (130mg). The suspension was stirred at 0℃ for 16h. The reaction mixture was diluted with EA and aq. A solution of potassium sodium tartrate was stirred for lh at rt. The layers were separated, and the org. phasel was further washed with water. The combined org. layers were dried over MgSO4, filtrated off and evaporated in vacuo. The crude was purified by CC (Buechi Sepacore, 5g cartridge, solvent A: DCM, solvent B: 3N ammonia in MeOH, gradient in %B: 0 to 5, flow rate: 6.0 mI/mm) to afford 224mg of colourless oil 4-Chloro-2-fluorobenzyl alcohol. LCMS: (A) tR = 0.68 mm; [M+H]: not visible.

References

[1] Patent: US2012/329788, 2012, A1. Location in patent: Page/Page column 22
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3463 - 3468
[3] Patent: US6100257, 2000, A
[4] Patent: EP1577290, 2005, A1. Location in patent: Page/Page column 107

4-Chloro-2-fluorobenzyl alcohol(56456-49-6)Related Product Information

• 4-Fluorobenzyl chloride
• alpha-Chloro-o-fluorotoluene
• 1,2-Difluorobenzene
• Benzyl chloroformate
• 4-Nitrobenzyl alcohol
• MCPA SODIUM
• 1,2-Dichloro-4-(chloromethyl)benzene
• Benzyl alcohol
• Transfluthrin
• 4-Fluorobenzaldehyde
• 3-Fluorobenzyl alcohol
• 4-Chlorobenzyl chloride
• 3-Chlorobenzyl chloride
• Ethyl acetate
• 2-Chlorobenzyl chloride
• Florfenicol
• Difluorochloromethane
• 4-Chloro-2-fluoro-5-sulfamylbenzoic acid