3-Amino-4-pyridinol Chemical Properties

Melting point:

145-149°C

Boiling point:

508.9±35.0 °C(Predicted)

Density 

1.320±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

5.04±0.18(Predicted)

color 

Light yellow to Brown

InChI

InChI=1S/C5H6N2O/c6-4-3-7-2-1-5(4)8/h1-3H,6H2,(H,7,8)

InChIKey

OIIBRAGQGFLUFI-UHFFFAOYSA-N

SMILES

C1=NC=CC(O)=C1N

CAS DataBase Reference

6320-39-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-40-41-37/38-22

Safety Statements 

22-26-36-39-37

HazardClass 

IRRITANT

HS Code 

29333999

3-Amino-4-pyridinol Usage And Synthesis

Uses

3-Amino-4-hydroxypyridine is a useful synthesis reagent.

Synthesis

4-Hydroxy-3-nitropyridine (2.8 g, 20.0 mmol) was dissolved in 150 mL of methanol and 280 mg of Pd/C catalyst was added. The air in the reaction flask was replaced with hydrogen, which was continuously vented, and the reaction was carried out at room temperature, and the progress of the reaction was monitored by thin-layer chromatography (TLC) until the completion of the reaction. The reaction mixture was filtrated, the filter cake was washed with methanol, the filtrates were combined and concentrated under reduced pressure to give 3-amino-4-hydroxypyridine as a black to orange oily liquid (1.98 g, 90% yield).

References

[1] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[2] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 15
[3] Patent: CN108373476, 2018, A. Location in patent: Paragraph 0390-0394
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[5] Roczniki Chemii, 1955, vol. 29, p. 119,127

3-Amino-4-pyridinol(6320-39-4)Related Product Information

• 4-AMINO-3-HYDROXY PYRIDINE
• 3-Amino-5-hydroxypyridine
• 3,4-Diamino-2-hydroxypyridine
• 2-Amino-3-hydroxypyridine
• 5,6-DICHLORONICOTINIC ACID ETHYL ESTER
• 4,5-DIAMINO-6-HYDROXYPYRIMIDINE SULFATE
• 2-Amino-5-hydroxypyridine
• 3-Amino-6-hydroxypyridine
• 6-Amino-2-hydroxypyridine
• 3-Amino-2-hydroxypyridine
• 6-AMINO-PYRIDIN-3-OL HYDROCHLORIDE
• 2-Aminopyridin-4-ol
• 4-AMINO-PYRIDIN-2-OL
• 3-Amino-2(1H)-pyridinone
• 4-Hydroxypyridine
• 4,5-Diamino-2-pyridinol
• 3-AMINO-4-HYDROXYPYRIDINE HYDROCHLORIDE