ANTI-CLUSTERIN, HUMAN Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

Storage Class

10 - Combustible liquids

ANTI-CLUSTERIN, HUMAN Usage And Synthesis

Uses

Anti-Clusterin antibody produced in rabbit has been used in immunohistochemical (IHC) staining (1:1,000 & 1:100).

Biological Activity

Clusterin (CLU) is a multifunctional plasma protein and a fluid-phase complement inhibitor. It mediates the complement terminal pathway. Clusterin is an ATP-independent small he at shock protein-like chaperone. It functions as a redox sensor and a lipid transporter. Clusterin is associated with many age-related diseases such as neurodegeneration and metabolic syndrome. It is involved in cancer progression, promotion, metastasis, and chemoresistance. Increased serum CLU levels are observed in type 2 diabetes (T2D). It is known to suppress proteotoxicity. Clusterin might show anti or proapoptotic activities. This protein is associated with different functions of the brain. A single nucleotide polymorphism (SNP) in the CLU gene might cause the development of late-onset Alzheimerμs disease (LOAD).