(R)-(-)-2-PHENYLBUTYRIC ACID Chemical Properties

Boiling point:

102-104 °C/0.4 mmHg (lit.)

alpha 

[α]D20 -92～-98゜ (c=4, C6H5CH3)

Density 

1.055 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.516

Flash point:

>230 °F

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Ethanol (Slightly), Toluene (Slightly)

form 

Liquid

color 

Clear colorless

optical activity

[α]20/D 93°, c = 0.9 in toluene

BRN 

2327346

CAS DataBase Reference

938-79-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

23-36

WGK Germany 

3

HS Code 

29163900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(R)-(-)-2-PHENYLBUTYRIC ACID Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

(R)-(-)-2-Phenylbutyric Acid, is the metabolite of Butamirate (B690025), which is a novel antitussive drug.

Purification Methods

Purify the acids by distillation at atmospheric pressure using an efficient column. The acid chlorides have b 106-107o/20mm, []D () and (+) 108o (c 2, *C6H6). [Levene et al. J Biol Chem 100 589 1933, Gold & Aubert Helv Chim Acta 41 1512 1958, ORD in heptane: Rothen & Levene J Chem Phys 7 975 1939, Beilstein 9 III 2461.]

(R)-(-)-2-PHENYLBUTYRIC ACID(938-79-4)Related Product Information

• BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID
• FMOC-(R)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID
• 2-Phenylbutyric acid ethyl ester
• FMOC-(S)-3-AMINO-4-(4-NITRO-PHENYL)-BUTYRIC ACID
• FMOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID
• FMOC-(S)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID
• (S)-4-AMINO-3-PHENYLBUTANOIC ACID
• (S)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE
• (S)-2-(Fmoc-amino)-4-phenylbutyric acid, Fmoc-L-homophenylalanine
• BOC-(S)-3-AMINO-4-(4-BROMO-PHENYL)-BUTYRIC ACID
• (3R)-3-Phenylbutyric acid
• BOC-(R)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID
• FMOC-(S)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID
• FMOC-(S)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
• FMOC-(R)-3-AMINO-4-(4-NITRO-PHENYL)-BUTYRIC ACID
• ethyl 4-bromo-4-phenyl-butanoate
• L-Homophe-OH