3,7-DIMETHYL-1-PROPARGYLXANTHINE Chemical Properties

Melting point:

204-205°C

storage temp. 

-20°C Freezer

solubility 

DMSO: ≥15 mg/mL

form 

solid

color 

white

CAS DataBase Reference

14114-46-6

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

3,7-DIMETHYL-1-PROPARGYLXANTHINE Usage And Synthesis

Chemical Properties

White Solid

Uses

A selective A2 adenosine receptor antagonist. Pharmacology: Ki vs [3H]NECA at A2 receptors in rat striatal membranes: 11± 3 uM; Ki vs [3H]CHA at A1 receptors in rat cerebral cortical membranes: 45 ± 4 uM.

Uses

3,7-Dimethyl-1-propargylxanthine (DMPX) has been used as an A₂ -adenosine receptor (AR) antagonist:

• to study its effects on potential modulation of motor output elicited by epidural spinal stimulation (ESS)
• to study the role of A_2a?receptor in elevating cyclic adenosine monophosphate (cAMP) levels
• to study its effects on the cell viability of human gastric cancer cell line

Biochem/physiol Actions

3,7-Dimethyl-1-propargylxanthine (DMPX) is a caffeine analog and A2-selective adenosine receptor (AR) antagonist.

3,7-DIMETHYL-1-PROPARGYLXANTHINE(14114-46-6)Related Product Information

• 7-methyl-8-(3-bromostyryl)-3,7-dimethyl-1-propargylxanthine
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• 3-HYDROXYPROPYL-7-METHYL-8-(3-METHOXYSTYRYL)-1-PROPARGYLXANTHINE, [METHYL-3H]
• 3,7-DIMETHYL-1-PROPARGYLXANTHINE
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