(+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE Chemical Properties

Melting point:

145-147 °C(lit.)

Boiling point:

283.4±0.0 °C(Predicted)

Density 

1.235±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

Acetone (Sparingly), Chloroform (Slightly), DMSO (Slightly)

form 

Solid

color 

White to Pale Beige

Stability:

Moisture Sensitive

CAS DataBase Reference

14166-21-3

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-42/43-41

Safety Statements 

26-27-36/37/39-37/39-24-23

WGK Germany 

3

HS Code 

29172090

MSDS

• Language:English Provider:SigmaAldrich

(+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE Usage And Synthesis

Uses

Trans-1,2-cyclohexanedicarboxylic anhydride can be used as a reagent to prepare hepatitis C virus (HCV) and granzyme B (indoline derivatives) inhibitors. It has also been employed in studies relating to the development of protein kinase C inhibitors.

Purification Methods

Crystallise the anhydride from *C6H6/Et2O. It has been obtained by heating the cis-acid or anhydride with HCl at 180o for 3hours. It can be obtained from the acid by heating in Ac2O. It sublimes at 125-135o/0.02mm. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Fichter & Simon Helv Chim Acta 17 1218 1934, Beilstein 9 IV 2802.]

(+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE(14166-21-3)Related Product Information

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