Concanavalin A Chemical Properties

Flash point:

39 °C

storage temp. 

-20°C

solubility 

PBS: 5 mg/mL, slightly hazy

form 

powder

color 

White to light yellow

Water Solubility 

Slightly soluble in water and phosfate buffered saline.

CAS DataBase Reference

11028-71-0

Safety Information

Hazard Codes 

Xn

Risk Statements 

10-42/43-63-40-20/21/22

Safety Statements 

36-24/25-45-36/37-23-22

RIDADR 

UN 1170 3/PG 3

WGK Germany 

3

RTECS 

GK6890000

F 

10-21

HS Code 

35040090

MSDS

• Language:English Provider:SigmaAldrich

Concanavalin A Usage And Synthesis

Chemical Properties

Lyophilized

Uses

Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.

Uses

Concanavalin A is a plant lectin that is a T-cell mitogen, and induces apoptosis in human fibroblasts.

Uses

As a reagent in analytical and preparative biochemistry; as a probe in studies of cell surface membrane dynamics and cell division.

Definition

A lectin mitogen that binds specifically to and agglutinates transforms into tumors. It binds to glucose and mannose residues in the surface.

General Description

Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family.

Hazard

Poison; teratogen; mutagen.

Biochem/physiol Actions

Concanavalin A is known to stimulate acute hepatic inflammation and acts as a T‐cell mitogen. It has inhibitory effect on hepatocellular carcinoma by inducing autophagy.

storage

-20°C

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