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2',7'-DICHLOROFLUORESCEIN

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2',7'-DICHLOROFLUORESCEIN Basic information

Product Name:
2',7'-DICHLOROFLUORESCEIN
Synonyms:
  • TIMTEC-BB SBB008847
  • DICHLORO (R) FLUORESCEIN
  • DICHLOROFLUORESCEIN
  • DICHLOROFLUORESCEIN TS
  • FLUORESCEIN DICHLORIDE
  • FLUORESCEIN 27
  • 2',7'-DICHLOROFLUORESCEIN
  • 2,7-DICHLOROFLUORESCEIN
CAS:
76-54-0
MF:
C20H10Cl2O5
MW:
401.2
EINECS:
200-968-6
Product Categories:
  • Fluorescent
  • Xanthene
  • D
  • Stains and Dyes
  • Stains&Dyes, A to
Mol File:
76-54-0.mol
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2',7'-DICHLOROFLUORESCEIN Chemical Properties

Melting point:
280 °C (dec.)(lit.)
Boiling point:
514.77°C (rough estimate)
Density 
0.79 g/mL at 20 °C
refractive index 
1.5300 (estimate)
Flash point:
12°C (53.6°F)
storage temp. 
room temp
solubility 
alcohol: passes test
pka
4.46(at 25℃)
form 
crystalline
color 
orange to red-brown, powder
PH Range
4.0 (colorless) - 6.6 (green)
Water Solubility 
Soluble in ethanol and methanol. Slightly dimethyl sulfoxide. Insoluble in water.
λmax
509nm
BRN 
58009
Stability:
Stable. Incompatible with strong oxidizing agents.
Major Application
Electroluminescent devices, sol-gel silica films, integrated circuits, photoresists, lithographic printing plates, recording material, LED devices, photoconductors, Solid-state dye laser, lithographic printing plates, inks, Fluorescent pH sensors, emissive probes, chemotherapeutic treatment of disease, phototherapeutic treatment of disease, photodynamic treatment of disease
InChIKey
NZVMJBGGAQSNLI-UHFFFAOYSA-N
CAS DataBase Reference
76-54-0(CAS DataBase Reference)
EPA Substance Registry System
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',7'-dichloro-3',6'-dihydroxy- (76-54-0)
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Safety Information

Hazard Codes 
Xi,F
Risk Statements 
36/37/38-36-67-11
Safety Statements 
26-36-16
RIDADR 
UN 1219 3/PG 2
WGK Germany 
3
RTECS 
NT8050000
TSCA 
Yes
HS Code 
3204 19 00

MSDS

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2',7'-DICHLOROFLUORESCEIN Usage And Synthesis

Chemical Properties

red to yellow solid

Uses

Widely used probe, e.g. for determination of carbohydrates by fluorescence densitometry after TLC and determination of H2O2 by chemiluminescence. Fluorescent additives used in indirect fluorimetric detection in OTC-HPLC.

Uses

2',7'-Dichlorofluorescein is used as an indicator and as a cellular antioxidant activity. It is also used for the determination of carbohydrates and hydrogen peroxide by fluorescence densitometry and chemiluminescence respectively. It is used as an indicator for argentometry by Fajans method. It is also involved in the cellular antioxidant activity assay. It is utilized as an additive in fluorescence and laser studies.
A new fluorescent sensor for Cd2+ and its application in living cells imaging. Tetrahedron Lett. 2015, 56 (11), 1322-1327.
Colorimetric and fluorogenic signaling of fluoride ions by thiophosphinated dichlorofluorescein. Dyes Pigm. 2015, 112, 170-175.

Uses

2',7'-Dichlorofluorescein is used as an indicator and as a cellular antioxidant activity. It is also used for the determination of carbohydrates and hydrogen peroxide by fluorescence densitometry and chemiluminescence respectively. It is used as an indicator for argentometry by Fajans method. It is also involved in the cellular antioxidant activity assay. It is utilized as an additive in fluorescence and laser studies.

Definition

2',7'-dichlorofluorescein is a member of 2-benzofurans. It has a role as a fluorochrome. It derives from a fluorescin.

Application

2',7'-dichlorofluorescein has been used as an oxidation-sensitive fluorescent probe to measure ROS (reactive oxygen species) formation in cells.

Biological Activity

2',7'-dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2′7′-dichlorofluorescein diacetate is oxidized to 2′7′-dichlorofluorescein in the presence of ROS (reactive oxygen species).

2',7'-DICHLOROFLUORESCEINSupplier

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