Sodium dichloroacetate Chemical Properties

Melting point:

198 °C (dec.) (lit.)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Methanol (Slightly), Water (Slightly)

form 

Powder

color 

White

PH

6.0 to 8.5(50g/L, 25 ℃)

Water Solubility 

soluble in cold water

Sensitive 

Moisture Sensitive

Stability:

Hygroscopic

InChIKey

LUPNKHXLFSSUGS-UHFFFAOYSA-M

CAS DataBase Reference

2156-56-1(CAS DataBase Reference)

EPA Substance Registry System

Sodium dichloroacetate (2156-56-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-40

Safety Statements 

26-37/39-36-36/37

RIDADR 

2811

WGK Germany 

2

RTECS 

AG9275000

HS Code 

29154000

MSDS

• Language:English Provider:Dichloroacetic acid sodium salt
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Sodium dichloroacetate Usage And Synthesis

Uses

Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic. Recent studies had found that DCA acts as a potential vasoprotective agent by inhibiting PDK2 and reducing coronary endarterium proliferation. Further, DCA promotes brain regeneration after cerebral ischemia, which indicates that DCA might play an important role in VD.

Chemical Properties

white powder

Uses

Treatment of neurologic injury (pyruvate dehydrogenase activator).

Uses

Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.

brand name

Ceresine (Cypros).

General Description

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Biological Activity

Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo .

storage

Desiccate at RT

Sodium dichloroacetate(2156-56-1)Related Product Information

• Dichloroacetic acid
• Sodium chloride
• Dichloroacetic acid methyl ester
• Trisodium phosphate
• Diclofenac sodium
• Sodium citrate
• Sodium benzoate
• Sodium acetate
• Sodium hydroxide
• Sodium chloroacetate
• Sodium bicarbonate
• Sodium chlorite
• Sodium diethyldithiocarbamate trihydrate
• Sodium dichloroisocyanurate
• Sodium dimethyl 5-sulphonatoisophthalate
• 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
• Chloroacetic acid
• SODIUM TRICHLOROACETATE