Sodium dichloroacetate
Sodium dichloroacetate Basic information
- Product Name:
- Sodium dichloroacetate
- Synonyms:
-
- dichloroacetate,sodiumsalt
- dichloro-aceticacisodiumsalt
- dichloroctansodny
- Sodiumdichloracetate
- NATRIUMDICHLORACETAT
- SDA
- SODIUM DICHLOROACETATE
- erlcyiuanna
- CAS:
- 2156-56-1
- MF:
- C2H3Cl2NaO2
- MW:
- 152.93
- EINECS:
- 218-461-3
- Mol File:
- 2156-56-1.mol
Sodium dichloroacetate Chemical Properties
- Melting point:
- 198 °C (dec.) (lit.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Powder
- color
- White
- PH
- 6.0 to 8.5(50g/L, 25 ℃)
- Water Solubility
- soluble in cold water
- Sensitive
- Moisture Sensitive
- Stability:
- Hygroscopic
- InChIKey
- LUPNKHXLFSSUGS-UHFFFAOYSA-M
- CAS DataBase Reference
- 2156-56-1(CAS DataBase Reference)
- EPA Substance Registry System
- Sodium dichloroacetate (2156-56-1)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-40
- Safety Statements
- 26-37/39-36-36/37
- RIDADR
- 2811
- WGK Germany
- 2
- RTECS
- AG9275000
- HS Code
- 29154000
MSDS
- Language:English Provider:Dichloroacetic acid sodium salt
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Sodium dichloroacetate Usage And Synthesis
Uses
Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic. Recent studies had found that DCA acts as a potential vasoprotective agent by inhibiting PDK2 and reducing coronary endarterium proliferation. Further, DCA promotes brain regeneration after cerebral ischemia, which indicates that DCA might play an important role in VD.
Chemical Properties
white powder
Uses
Treatment of neurologic injury (pyruvate dehydrogenase activator).
Uses
Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.
brand name
Ceresine (Cypros).
General Description
Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.
Biological Activity
Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo .
storage
Desiccate at RT
Sodium dichloroacetateSupplier
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Sodium dichloroacetate(2156-56-1)Related Product Information
- Dichloroacetic acid
- Sodium chloride
- Dichloroacetic acid methyl ester
- Trisodium phosphate
- Diclofenac sodium
- Sodium citrate
- Sodium benzoate
- Sodium acetate
- Sodium hydroxide
- Sodium chloroacetate
- Sodium bicarbonate
- Sodium chlorite
- Sodium diethyldithiocarbamate trihydrate
- Sodium dichloroisocyanurate
- Sodium dimethyl 5-sulphonatoisophthalate
- 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- Chloroacetic acid
- SODIUM TRICHLOROACETATE