2-ETHOXYPHENYL ISOTHIOCYANATE Chemical Properties

Boiling point:

223 °C

Density 

1.14

storage temp. 

Keep Cold

Specific Gravity

1.14

Appearance

Colorless to light yellow Liquid

Sensitive 

Moisture Sensitive/Lachrymatory

CAS DataBase Reference

23163-84-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,T,Xi

Risk Statements 

20/21/22-36/37/38-36

Safety Statements 

26-36/37/39

Hazard Note 

Toxic/Corrosive/Lachrymatory/Moisture Sensitive

HazardClass 

KEEP COLD, LACHRYMATOR, TOXIC

HS Code 

2930909899

2-ETHOXYPHENYL ISOTHIOCYANATE Usage And Synthesis

Uses

2-Ethoxyphenyl isothiocyanate is an isothiocyanate compound, an important functional substance in natural products and pharmaceutical active compounds. Isothiocyanates are a class of compounds with the general formula RN=C=S, and are important intermediates in organic synthesis, with wide applications in mineral processing, pharmaceuticals, pesticides, and dyes.

Synthesis

Take 4-ethoxyaniline (2.19mol) and 309.2g triethylamine (3.06mol) in a 5000mL three-mouth round bottom flask, add 1000mL of ethyl acetate, cooled in an ice bath and stirred mechanically. When the temperature of the mixture was reduced to 0 ??~5 ??, 299.2 g of CS2 (3.93 mol) was added slowly by dropping with a constant pressure dropping funnel, and the temperature of the reaction solution was controlled to be below 30 ?? by magnetic stirring while dropping. After the dropwise addition, the reaction solution was stirred magnetically at room temperature (10-30 ?? range) for one hour; at this temperature, 299.2 g of CS2 (3.93 mol) and DMAP catalyst were added to the reaction solution, and the reaction was stirred at 30±2.5 ?? for 1.5 h. At the end of the reaction, the reaction solution was washed with an acid solution twice, and the total amount of acid consumed for washing was 1.5 times that of triethylamine, and washed to neutrality with saturated saline. The reaction solution was washed with acid solution twice, the total acid consumption was 1.5 times of triethylamine, and then washed with saturated saline to neutral. The organic phase was evaporated and concentrated to obtain 2-ethoxyphenyl isothiocyanate.

2-ETHOXYPHENYL ISOTHIOCYANATE(23163-84-0)Related Product Information

• Potassium thiocyanate
• 2-ETHYLPHENYL ISOTHIOCYANATE
• 2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE
• 3,4-Difluorophenyl isothiocyanate
• 4-CYANOPHENYL ISOTHIOCYANATE
• 4-METHOXYBENZYL ISOTHIOCYANATE
• Phenyl isothiocyanate
• 2,3-DIMETHYLPHENYL ISOTHIOCYANATE
• BENZYL ISOTHIOCYANATE
• 4-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE
• 3,4-DICHLOROPHENYL ISOTHIOCYANATE
• 2-BROMOPHENYL ISOTHIOCYANATE
• 4-TERT-BUTYLPHENYL ISOTHIOCYANATE
• 4-CHLOROBENZOYL ISOTHIOCYANATE
• 4-ETHOXYPHENYL ISOTHIOCYANATE,P-ETHOXYPHENYL ISOTHIOCYANATE,4-Ethoxyphenyl isothiocyanate 97%
• 2-ETHOXYPHENYL ISOTHIOCYANATE
• 1,4-diethoxy-2-isothiocyanatobenzene
• 4-(2-(2-METHOXYETHOXY)ETHOXYPHENYL)ISOTHIOCYANATE