2,4-Dichlorobenzylamine Chemical Properties

Melting point:

309-311 °C(Solv: N,N-dimethylformamide (68-12-2))

Boiling point:

83-84 °C5 mm Hg(lit.)

Density 

1.308 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.578(lit.)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.31±0.10(Predicted)

form 

Liquid

color 

Clear colorless

Sensitive 

Air Sensitive

BRN 

775667

CAS DataBase Reference

95-00-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanamine, 2,4-dichloro-(95-00-1)

EPA Substance Registry System

Benzenemethanamine, 2,4-dichloro- (95-00-1)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-24/25-23

RIDADR 

UN 2735 8/PG 3

WGK Germany 

3

F 

9

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214990

MSDS

• Language:English Provider:2,4-Dichlorobenzylamine
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2,4-Dichlorobenzylamine Usage And Synthesis

Application

2,4-Dichloroaniline is an important dye and pharmaceutical intermediate, widely used in fine chemical industries such as pesticides, pharmaceuticals, dyes, and photosensitive materials.

Chemical Properties

clear colourless liquid

Synthesis

Benzaldehyde oxime (CAS: 56843-28-8, 0.121 g, 1 mmol) was used as a starting material, mixed with nano Fe3O4 (0.046 g, 0.2 mmol, average particle size of about 70 nm) in a porcelain mortar and pestle and ground. Subsequently, ZrCl4 (0.233 g, 1 mmol) was added and the mixture was continued to be ground to homogeneity at room temperature. The mortar was heated in an oil bath to raise the temperature of the reaction mixture to 75-80°C. At this temperature, NaBH3CN (0.314 g, 5 mmol) was added in batches and the reaction mixture was continuously ground for 15 minutes. Upon completion of the reaction, the reaction was quenched by the addition of H2O (5 mL) and stirred for 5 min. The reaction mixture was extracted with EtOAc (2 x 5 mL), the organic phases were combined and dried with anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure to give the pure 2,4-dichlorobenzenemethanamine liquid product in 93% yield (0.1 g, see Table 2, entry 1).

References

[1] Journal of the Chinese Chemical Society, 2005, vol. 52, # 1, p. 109 - 112
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 9, p. 3323 - 3326
[3] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 9, p. 3448 - 3452
[4] Journal of the Iranian Chemical Society, 2015, vol. 12, # 5, p. 873 - 878
[5] Journal of Medicinal Chemistry, 1984, vol. 27, # 9, p. 1111 - 1118

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