(+)-DIACETYL-L-TARTARIC ANHYDRIDE Chemical Properties

Melting point:

130-135 °C(lit.)

Boiling point:

316.55°C (rough estimate)

Density 

1.5197 (rough estimate)

refractive index 

90 ° (C=0.5, CHCl3)

storage temp. 

2-8°C

solubility 

Acetone, Chloroform (Slightly, Heated)

form 

Crystals or Needles

color 

White

optical activity

[α]20/D +59°, c = 6 in acetone

Water Solubility 

Soluble in methanol and dichloromethane. Slightly soluble in water.

Sensitive 

Moisture Sensitive

BRN 

87315

CAS DataBase Reference

6283-74-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10-21

HS Code 

29321900

MSDS

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(+)-DIACETYL-L-TARTARIC ANHYDRIDE Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

Di-O-acetyl-L-tartaric Anhydride (cas# 6283-74-5) is a compound useful in organic synthesis.

Uses

(+)-O,O′-Diacetyl-L-tartaric anhydride may be used as a chiral derivatizating agent in the following:

• determination of enantiomeric vigabatrin in mouse serum samples using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-M)????????
• determination of trantinterol in rat plasma by ultra performance liquid chromatography–electrospray ionization mass spectrometry (UPLC–MS/MS)

General Description

(+)-O,O′-Diacetyl-L-tartaric anhydride is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed as a reagent for the chiral derivatization of amino alcohols. It also reacts with alkanoamines in aprotic medium containing trichloroacetic acid and produces tartaric acid monoesters.

Purification Methods

If the IR is good, i.e. no OH bands, then keep it in a vacuum desiccator overnight (over P2O5/paraffin) before use. If OH bands are present then reflux 4g in Ac2O (12.6mL) containing a few drops of conc H2SO4 for 10minutes (use a relatively large flask), pour onto ice, collect the crystals, wash with dry *C6H6 (2 x 2mL), stir with 17mL of cold Et2O, filter and dry in it a vacuum desiccator as above, or store it in dark evacuated ampoules under N2 in small aliquots. It is not very stable in air, the melting point of the crystals drop one degree in the first four days then remains constant (132-134o). If placed in a stoppered bottle, it becomes gummy and the m falls 100o in three days. Recrystllisation leads to decomposition. If good quality anhydride is required it, should be prepared freshly from tartaric acid. It sublimes in a CO2 atmosphere. [Shriner & Furrow Org Synth Coll Vol IV 242 1963, Bell Aust J Chem 34 671 1981, Beilstein 18 III/IV 2296.]

(+)-DIACETYL-L-TARTARIC ANHYDRIDE(6283-74-5)Related Product Information

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• (-)-DIACETYL-D-TARTARIC ANHYDRIDE