1-(4-Methoxyphenyl)piperazine dihydrochloride Chemical Properties

Melting point:

240 °C (dec.)(lit.)

storage temp. 

-20°C Freezer

solubility 

DMF: 5 mg/ml; DMSO: 30 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

powder to crystal

color 

White to Light yellow to Light red

Water Solubility 

very faint turbidity

Sensitive 

Hygroscopic

BRN 

4275784

InChI

InChI=1S/C11H16N2O.2ClH/c1-14-11-4-2-10(3-5-11)13-8-6-12-7-9-13;;/h2-5,12H,6-9H2,1H3;2*1H

InChIKey

MMXANKLJIHSIQH-UHFFFAOYSA-N

SMILES

N1(C2=CC=C(OC)C=C2)CCNCC1.[H]Cl.[H]Cl

CAS DataBase Reference

38869-47-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

28A-26-36-24/25

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:1-(4-Methoxyphenyl)piperazine dihydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-(4-Methoxyphenyl)piperazine dihydrochloride Usage And Synthesis

Description

1-(4-Methoxyphenyl)piperazine dihydrochloride is a piperazine derivative with euphoric, stimulant properties comparable to those produced by amphetamine. It is assumed to have a mixed mechanism of action, with serotonergic and dopamine antagonistic properties in a similar fashion to 3,4-methylenedioxymethamphetamine. Also, its metabolism has been described. This product is intended for research and forensic purposes.

Chemical Properties

Off-White Powder

Uses

An intermediate in the synthesis of Itraconazole (I937500).

Uses

1-(4-Methoxyphenyl)piperazine dihydrochloride is a piperazine derivative with euphoric, stimulant properties comparable to those produced by amphetamine. It is assumed to have a mixed mechanism of action, with serotonergic and dopamine antagonistic properties in a similar fashion to 3,4-methylenedioxymethamphetamine. Also, its metabolism has been described. This product is intended for research and forensic purposes.

References

[1] ROLAND F STAACK  Hans H M. Metabolism of designer drugs of abuse.[J]. Current drug metabolism, 2005, 6 3: 259-274. DOI: 10.2174/1389200054021825
[2] M.D. ARBO  H. F C  M L Bastos. Piperazine compounds as drugs of abuse[J]. Drug and alcohol dependence, 2012, 122 3: Pages 174-185. DOI: 10.1016/j.drugalcdep.2011.10.007

1-(4-Methoxyphenyl)piperazine dihydrochloride(38869-47-5)Related Product Information

• 4-Methoxybenzoic acid
• (Trifluoromethoxy)benzene
• Piperazine
• Methoxyacetic acid
• 4-Methoxybenzylchloride
• 4-Methoxyphenylacetone
• m-Anisyl alcohol
• 4-Methoxyphenylhydrazine hydrochloride
• Anisole
• 4-Methoxyphenol
• 4-(Trifluoromethoxy)aniline
• p-Anisaldehyde
• 1-(4-Methoxyphenyl)piperazine
• p-Anisidine
• Dihydrochloride
• 1-(2-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE
• 1-(4-Methoxyphenyl)piperazine hydrochloride
• 1-(3-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE,1-(m-Methoxyphenyl)-piperazine dihydrochloride