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NETROPSIN

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NETROPSIN Basic information

Product Name:
NETROPSIN
Synonyms:
  • NETROPSIN
  • ia887
  • k-117
  • n,4’-bi(pyrrole-2-carboxamide),n’-(2-carbamoylethyl)-4-((2-guanidinoacetimidoy
  • t1384
  • NETROPSIN ULTRA PURE GRADE 98+%
  • ultrapuregrade
  • Congocidin, Sinanomycin
CAS:
1438-30-8
MF:
C18H26N10O3
MW:
430.46
EINECS:
634-294-2
Mol File:
1438-30-8.mol
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NETROPSIN Chemical Properties

Melting point:
171-173℃
Boiling point:
544.74°C (rough estimate)
Density 
1.3374 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
pka
14.37±0.70(Predicted)
color 
faint yellow
EPA Substance Registry System
Netropsin (1438-30-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DW2973000
Toxicity
LD50 oral in mouse: 300mg/kg
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NETROPSIN Usage And Synthesis

Uses

Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity[1][2].

References

[1] Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60. DOI:10.1016/0167-4781(91)90036-l
[2] Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73(1): 341-343.

NETROPSINSupplier

Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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Chengdu Ai Keda Chemical Technology Co., Ltd.
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4008-755-333 18080918076
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T&W GROUP
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021-61551611 13296011611
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Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com
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