Tetraisopropyl methylenediphosphonate Chemical Properties

Boiling point:

155 °C/0.5 mmHg (lit.)

Density 

1.08 g/mL at 25 °C (lit.)

vapor pressure 

0.017Pa at 20℃

refractive index 

n20/D 1.431(lit.)

Flash point:

320 °F

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

color 

Clear Colourless to Yellow

Specific Gravity

1.080

Water Solubility 

Insoluble in water.

BRN 

1080180

InChIKey

FKHXXJRKGVDPQP-UHFFFAOYSA-N

LogP

1.3 at 20℃

CAS DataBase Reference

1660-95-3(CAS DataBase Reference)

NIST Chemistry Reference

Tetraisopropyl methylenediphosphonate(1660-95-3)

EPA Substance Registry System

Phosphonic acid, methylenebis-, tetrakis(1-methylethyl) ester (1660-95-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-36-39

WGK Germany 

3

TSCA 

Yes

HS Code 

29319090

MSDS

• Language:English Provider:Tetraisopropyl methylenediphosphonate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tetraisopropyl methylenediphosphonate Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Tetraisopropyl Methylenediphosphonate is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents. Also used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase.

Uses

Tetraisopropyl methylenediphosphonate [T(iPr)MDP] forms a synergistic mixture with hydrogen dicarbollylcobaltate in nitrobenzene which was used in the extraction of europium and americium.
It may be used in the synthesis of the following:

• tetraisopropyl ethenylidenebisphosphonate.
• tetraisopropyl 4-acetylthiobutane-1,1-diphosphonate
• tetraisopropyl 2-(3,5-bis(bromomethyl)phenyl)ethane-1,1-diphosphonate

General Description

Tetraisopropyl methylenediphosphonate (IPCP) is a tetraisopropyl ester of methylenediphosphonic acid. It is an electroneutral ligand, reported to be synthesized from triisopropyl phosphate. Powder electron paramagnetic resonance (EPR) studies of tris complexes of Cu(II) complexes with IPCP has been analyzed.

Tetraisopropyl methylenediphosphonate(1660-95-3)Related Product Information

• N,N-Dimethylallylamine
• Triisopropyl phosphite
• 2-Hydroxypropyl methacrylate
• 3-Methyl-2-butanone
• Titanium tetraisopropanolate
• Isopropyl myristate
• METHYLENEDIPHOSPHONIC ACID
• ALLYL METHYL ETHER
• Cyclopropyl methyl ketone
• methanedisulphonyl dichloride
• TETRAMETHYL METHYLENEDIPHOSPHONATE
• Orthophosphorus acid
• Methanedisulphonic acid
• Methylene dithiocyanate
• TETRAISOPROPYL ORTHOSILICATE
• TETRAISOPROPYL 1,2-ETHYLENEDIPHOSPHONATE
• TETRAISOPROPYL METHYLENEDIPHOSPHONATE, 9 7%
• 2-METHYLPENTANE