BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE Chemical Properties

Density 

1.36

storage temp. 

-15°C

pka

10.06±0.46(Predicted)

BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE Usage And Synthesis

Uses

BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

To a solution of thioanilide 7 (2 mmol) dissolved by gentle warming at 40 °C and then cooled to 0 °C in glacial acetic acid (diluted with 5% water, 15 mL) was added NaNO2 (0.21 g, 3 mmol) in portions over 5 min with stirring. After 30 min, ice water (～100 mL) was added, and the precipitated product was filtered and washed with water. The orange solid was dried in vacuo at rt overnight and then at 50 °C for 4 h to afford benzotriazoles 1-(N-BOC-L-thionophenylalaninyl)-6-nitrobenzotriazole (9b): yield 81%. as amorphous solids of sufficient purity for use in the next step.

BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE(184951-87-9)Related Product Information

• 2-(1H-BENZO[D][1,2,3]TRIAZOL-1-YL)ETHANAMINE
• BOC-THIONOALA-1-(6-NITRO)BENZOTRIAZOLIDE
• 2-AMINO-THIOPROPIONAMIDE
• BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE
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• BOC-L-ALANINE THIOAMIDE
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• 2-(1H-1,2,3-TRIAZOL-1-YL)ETHANAMINE
• TERT-BUTYL 2-AMINO-2-THIOXOETHYLCARBAMATE
• 5-NITROBENZOTRIAZOLE
• 2-AMINO-3-PHENYL-THIOPROPIONAMIDE