2-BENZYLOXY-5-BROMO-PYRIMIDINE Chemical Properties

Melting point:

100-103°C

Boiling point:

392.6±44.0 °C(Predicted)

Density 

1.499±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-0.21±0.22(Predicted)

Appearance

Light yellow to yellow Solid

CAS DataBase Reference

742058-39-5

2-BENZYLOXY-5-BROMO-PYRIMIDINE Usage And Synthesis

Uses

2-(Benzyloxy)-5-bromopyrimidine is a pharmaceutical intermediate compound that can be used in the preparation of protein tyrosine phosphatase 2 (SHP2) inhibitors.

Synthesis

Synthesis of 2-(Benzyloxy)-5-bromopyrimidine: At room temperature, 5-bromo-2-chloropyrimidine (3.00 g, 15.51 mmol), benzyl alcohol (1.84 g, 17.06 mmol) and DMF (10 mL) were sequentially added to the flask.  Potassium tert-butylate (2.82 g, 23.26 mmol) was added in portions.  The mixture reacted at room temperature for 2 hours.  Water was added, and the mixture was filtered to yield 2.10 g of the pure product, a yield of 51%.

2-BENZYLOXY-5-BROMO-PYRIMIDINE(742058-39-5)Related Product Information

• Butyl acetate
• 5-Bromopyrimidine
• 2-BENZYLOXY-5-BROMO-PYRIMIDINE
• 2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE
• 5-BROMO-2-ETHOXY-PYRIMIDINE