Ethyl 5-cyanoindole-2-carboxylate Chemical Properties

Boiling point:

419.3±25.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

13.63±0.30(Predicted)

Appearance

Off-white to light brown Solid

Safety Information

HS Code 

2933998090

Ethyl 5-cyanoindole-2-carboxylate Usage And Synthesis

Uses

Ethyl 5-cyanoindole-2-carboxylate is an important chemical raw material for the preparation of pril drugs and dye products, and is also widely used in the pharmaceutical industry.

Synthesis

General procedure for the synthesis of ethyl 5-cyano-1H-indole-2-carboxylate: a suspension of cuprous cyanide (27 mg, 0.3 mmol) and ethyl 5-bromoindole-2-carboxylate (138) in 500 μL of DMF was stirred and reacted for 7 hours at 155 °C. After completion of the reaction, it was purified by silica gel column chromatography (3 × 15 cm, SiO?, 20% EtOAc/hexane as eluent) to afford the target product, ethyl 5-cyano-1H-indole-2-carboxylate (139) (34 mg, 63% yield), as a white solid with melting point of 181-182 °C.

References

[1] Patent: US2005/26987, 2005, A1. Location in patent: Page 23

Ethyl 5-cyanoindole-2-carboxylate(105191-13-7)Related Product Information

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• Ethanol
• Ethyl acetate
• Ethyl N-cyanoethanimideate
• Indole-2-carboxylic acid
• Ethylparaben
• Trinexapac-ethyl
• Tris(trimethylsilyl)phosphate
• Indole-3-butyric acid
• RESMETHRIN
• Ethyl cyanoacetate
• Indole
• ETHYL 2-CYANOACRYLATE
• Ethyl formate
• ISOXADIFEN-ETHYL
• Indometacin
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• Diethyl ether