BERBERINE CHLORIDE
BERBERINE CHLORIDE Basic information
- Product Name:
- BERBERINE CHLORIDE
- Synonyms:
-
- Berberine (berberine hydrochloride)
- Berberine chloride hydrate 97%
- 9,10-DiMethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-iuM chloride hydrate
- Berberine chloride hydrate technical, >=90% (AT)
- Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride, hydrate (1:1:)
- LABOTEST-BB LT00440956
- CI 75160
- BERBERIN HCL
- CAS:
- 141433-60-5
- MF:
- C20H20ClNO5
- MW:
- 389.83
- EINECS:
- 211-195-9
- Product Categories:
-
- Alkaloids
- Biochemistry
- Miscellaneous Natural Products
- Isoquinoline Alkaloids
- Mol File:
- 141433-60-5.mol
BERBERINE CHLORIDE Chemical Properties
- Melting point:
- 204-206 °C (dec.)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- Colour Index
- 75160
- color
- Pale Yellow to Yellow
- Water Solubility
- Soluble in water.
- Sensitive
- Light Sensitive
- Merck
- 14,1154
- BRN
- 3836585
- Stability:
- Hygroscopic
- InChIKey
- VKJGBAJNNALVAV-UHFFFAOYSA-M
- CAS DataBase Reference
- 141433-60-5(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
BERBERINE CHLORIDE Usage And Synthesis
Description
Berberine chloride occurs together with Neprotine (q.v.) in Berberis insignis Hook, B. umbellata Wall and Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng.). It is optically inactive and crystallizes from H2O with 5.5 H2O. It yields crystal_x0002_line salts, e.g. the nitrate, m.p. 265-7°C (dec.); sulphate, m.p. 271-3°C (dec.) and the picrate, m.p. 231°C (dec.). The base also furnishes a methyl ether, m.p. 265°C and on catalytic hydrogenation gives the tetrahydro derivative, m.p. 213-5°C (dec.). The ultraviolet spectrum resembles that of berberine (q.v.). Oxidation with KMn04 in Me2CO gives hemipinic acid, identified as the ethylimide, m.p. 90°C.
Uses
Berberine chloride is mainly used to treat gastroenteritis, dysentery and other intestinal infections, conjunctivitis and suppurative otitis media.
General Description
Berberine chloride is an alkaloid with antibiotic properties. Berberine chloride induces reactive oxygen species (ROS) production and inhibits DNA topoisomerase. It has anti-tumor properties.
References
Orekhov.,J. Amer. Pharm. Assoc., 30,247, (1941)
Chatterjee., ibid, 33,205,210 (1944)
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BERBERINE CHLORIDE(141433-60-5)Related Product Information
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- Ammonium chloride
- Chloral hydrate
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- Methylene Chloride
- hydrate
- hydrazine hydrate
- BERBERINE CHLORIDE
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- BERBERINE CHLORIDE EXTRACT JP 12
- BERBERINE, ACETONE ADDUCT
- 2-[[(2-ethylphenyl)(2-hydroxyethyl)amino]methyl]-3,3-difluoro-Propanenitrile
- Berberine Hcl