Methylbutyric acid Chemical Properties

Melting point:

-70°C

Boiling point:

176-177 °C(lit.)

Density 

0.936 g/mL at 25 °C(lit.)

vapor pressure 

0.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.405(lit.)

FEMA 

2695 | 2-METHYLBUTYRIC ACID

Flash point:

165 °F

pka

4.8(at 25℃)

CAS DataBase Reference

600-07-7(CAS DataBase Reference)

NIST Chemistry Reference

2-Methylbutyric acid(600-07-7)

EPA Substance Registry System

Butanoic acid, 2-methyl-(600-07-7)

Safety Information

Hazard Codes 

C

Risk Statements 

21/22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 3

WGK Germany 

1

RTECS 

EK7897000

F 

13

HazardClass 

8

PackingGroup 

III

MSDS

• Language:English Provider:DL-2-Methylbutyric acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methylbutyric acid Usage And Synthesis

Chemical Properties

Colorless liquid. The boiling point is 177°C, 84°C (2.8kPa), the relative density (20/17°C) is 0.938, and the refractive index (nD20) is 1.4055. Soluble in water, ethanol, ether.

Uses

Methylbutyric acid can be used as an organic synthesis intermediate.

Definition

ChEBI: 2-methylbutyric acid is a methylbutyric acid comprising a butyric acid core carrying a 2-methyl substituent. Produced from amino acid leucine during nutrient starvation in bacteria. It has a role as a bacterial metabolite and a human metabolite. It is a conjugate acid of a 2-methylbutyrate.

Synthesis

2-Chlorobutane is made into Grignard reagent, which is then reacted with carbon dioxide, and the reaction mixture is hydrolyzed with 25% sulfuric acid to generate Methylbutyric acid. Yield 76-86%.

Methylbutyric acid(600-07-7)Related Product Information

• Malic acid
• Hydrocortisone-17-butyrate
• Ethyl 2-(Chlorosulfonyl)acetate
• Indole-3-butyric acid
• 4-Aminobutyric acid
• CELLULOSE ACETATE BUTYRATE
• Citric acid
• Folic acid
• Butyric Acid
• 2,2-Bis(hydroxymethyl)butyric acid
• MCPB
• Hyaluronic acid
• Ascoric Acid
• 2-Methyl butyric acid
• (R)-2-[2-Chloro-4-(trifluoromethyl)anilino]-3-methylbutyric acid
• (S)-2-(Aminoacetyl)amino-3-methylbutyric acid,(S)-2-Glycylamino-3-methylbutyric acid
• 2-Methylbutyric acid pentyl ester
• (2R)-2-(Benzyloxycarbonylamino)-3-methylbutyric acid,(R)-2-(Benzyloxycarbonylamino)-3-methylbutyric acid