6-Chloro-1-tetralone Chemical Properties

Melting point:

53 °C

Boiling point:

150°C/0.7mmHg(lit.)

Density 

1.248±0.06 g/cm3(Predicted)

refractive index 

1.59

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to lump

color 

White to Yellow to Orange

CAS DataBase Reference

26673-31-4

Safety Information

HS Code 

2914390090

6-Chloro-1-tetralone Usage And Synthesis

Uses

6-Chloro-1-tetralone is a novel and potent intermediate used for synthesis of pharmaceutical compounds.

Synthesis

A solution of sodium nitrite (173 mg, 2.51 mmol) in water (5 mL) at 0 °C (ice-bath) was added to a magnetically stirred suspension of 6-Amino-1-tetralone (360 mg, 2.23 mmol) in aqueous hydrochloric acid (10 mL, 6 M) at 0 °C. This reaction mixture was added dropwise to a solution of copper(I) chloride (267 mg, 2.70 mmol) in concentrated hydrochloric acid (5 mL) at 0 °C. It was allowed to warm up to room 100 temperature and stirred for a further 2 h after which it was neutralised with solid sodium carbonate, extracted with ethyl acetate (3 × 20 mL) and concentrated in vacuo to give slightly yellow oil. This material was subjected to flash chromatography (50% chloroform in hexane) and concentration of the appropriate fractions afforded 6-chloro-1-tetralone (180 mg, 45%) as a waxy solid.

6-Chloro-1-tetralone(26673-31-4)Related Product Information

• 1-Chloronaphthalene
• Epichlorohydrin
• 1,2,3,4-Tetrahydronaphthalene
• Chlortalidone
• Trazodone
• Dihydromyrcenol
• Chlormezanone
• beta-Tetralone
• Decahydronaphthalene
• Nabumetone
• 1-Tetralone
• Chloroacetic acid
• 6-CHLORO-2-TETRALONE
• 6,7-Dichloro-2-tetralone
• 8-Chloro-1-tetralone,8-Chloro-α-Tetralone,8-CHLORO-A-TETRALONE
• Difluorochloromethane
• 5-Chloro-2-tetralone,7-Chloro-2-tetralone
• KETAMINE/ZYLAZINE SOLUTION--SCHEDULE*III ITEM