ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Chemical Properties

Melting point:

245-250 °C(lit.)

Boiling point:

324.41°C (rough estimate)

Density 

1.3175 (rough estimate)

refractive index 

1.5400 (estimate)

storage temp. 

2-8°C

solubility 

methanol: 10 mg/mL, clear

form 

powder

pka

0.85±0.10(Predicted)

color 

yellow

BRN 

3271427

InChIKey

AFVLVVWMAFSXCK-VMPITWQZSA-N

CAS DataBase Reference

28166-41-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10-23

HS Code 

29269090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

inhibitor of mitochondrial pyruvate transport

Uses

α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Uses

α-Cyano-4-hydroxycinnamic acid(CHC) was used as a matrix for peptides and nucleotides in mass spectroscopic analysis. It was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Definition

ChEBI: Alpha-cyano-4-hydroxycinnamic acid is a monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides. It has a role as a MALDI matrix material. It is a nitrile, a member of phenols and a monohydroxycinnamic acid.

General Description

α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase.

Biochem/physiol Actions

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM).

storage

Store at +4°C

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID(28166-41-8)Related Product Information

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