DBCO-PEG1-amine Chemical Properties

Boiling point:

730.9±60.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

15.15±0.46(Predicted)

DBCO-PEG1-amine Usage And Synthesis

Description

DBCO-PEG1-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

DBCO-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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