BRUSATOL Chemical Properties

Boiling point:

727.5±60.0 °C(Predicted)

Density 

1.46±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

8.58±0.15(Predicted)

CAS DataBase Reference

114420-67-6

BRUSATOL Usage And Synthesis

Physical Form

Powder

Description

Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte meiosis has not been addressed.

Uses

Clinically, the research shows brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism, and it provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity. Brusatol overcomes chemoresistance through inhibition of protein translation.

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