L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide
L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide Basic information
- Product Name:
- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide
- Synonyms:
-
- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide
- CAS:
- 454487-07-1
- MF:
- C36H65N17O12S2
- MW:
- 992.14
- Mol File:
- 454487-07-1.mol
L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide Chemical Properties
- Density
- 1.65±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 2.95±0.70(Predicted)
- color
- White to off-white
- Sequence
- Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys (Disulfide bridge: Cys1-Cys9)
L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide Usage And Synthesis
Uses
LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells[1].
in vivo
LyP-1 (8?weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide[1].The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×106?photon/cm2/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide[1].
References
[1] Fan Zhang, et al.Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide. Amino Acids. 2012 Jun;42(6):2343-51. DOI:10.1007/s00726-011-0976-1
[2] Ningning Song, et al. Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Deliv. 2019 Dec;26(1):363-375. DOI:10.1080/10717544.2019.1587047
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