3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE Chemical Properties

storage temp. 

Desiccate at RT

solubility 

Soluble to 100 mM in DMSO

form 

Powder

color 

Light yellow to yellow

CAS DataBase Reference

37804-11-8

3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE Usage And Synthesis

Uses

ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist)[1].

Biological Activity

Antagonist at the mGlu 5 receptor (K i = 295 nM). Inhibits human mGlu 5 receptor-mediated calcium flux with an IC 50 of 134 nM.

References

[1] Wang H, et al. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28(17):4385-97. DOI:10.1523/JNEUROSCI.0646-08.2008

3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE(37804-11-8)Related Product Information

• Pyrazinecarboxaldehyde, 5-(dimethylamino)- (9CI)
• 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE
• 3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE