Ethylhexylglycerin Chemical Properties

Boiling point:

325°C

Density 

0.962

refractive index 

1.4490 to 1.4530

Flash point:

152°C(lit.)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Oil

pka

13.67±0.20(Predicted)

color 

Colourless

Odor

Characteristic

InChI

InChI=1S/C11H24O3/c1-3-5-6-10(4-2)8-14-9-11(13)7-12/h10-13H,3-9H2,1-2H3

InChIKey

NCZPCONIKBICGS-UHFFFAOYSA-N

SMILES

C(O)C(O)COCC(CC)CCCC

LogP

2.470 (est)

CAS DataBase Reference

70445-33-9

Safety Information

Hazard Codes 

Xi

Risk Statements 

41-52/53

Safety Statements 

26-39-61

RTECS 

TY6462200

HS Code 

2905399590

Ethylhexylglycerin Usage And Synthesis

Description

Ethylhexylglycerin is also named as 3-(2-Ethylhexoxy)propane-1,2-diol or octoxyglycerin. It is a glyceryl ether. It is used as a weak preservative, as skin conditioning agent with effective wetting ability. It is used with phenoxyethanol in cosmetics to obtain better protection against microbial growth.

Chemical Properties

Ethylhexylglycerin is a glycerol monoalkylether of defined structure and high purity,with a 2-ethylhexyl group bound to the primary hydroxyl function of the glycerol molecule. Due to the fact that it is a crystal-clear,colourless liquid with a slightly characteristic odour it is well suited for the use in cosmetic products. Although it is less soluble in water(<0.1% at 25℃),it is more easily soluble in most common cosmetic alcohols and glycols as well as oils.Ethylhexylglycerin is rather stable, e.g. against hydrolysis and elevated temperatures and compatible with cosmetic ingredients.
Ethylhexylglycerin is globally approved and as a new substance accords with the European legislation listed on the ELINCS file.
International Approvals
Europe / USA: INCl name: Ethylhexylglycerin
Australia: AICS/NICNAS(NA/966)，TGA
Canada:DSL
Japan:
ENCS as glycerin monoalkyl(or alkenyl,C8-C24)ether(No.: 2-414)
CLS 199

Uses

Ethylhexylglycerin is a natural preservative, used as an alternative to parabens products. It is derived from natural glycerin. Also used as a deodorizer and skin conditioner.
Ethylhexylglycerin is a glyceryl ether and serves as an emollient solvent and a fixative with antimicrobial properties, and it is reported to enhance uptake of preservatives in microorganisms. It is often used as an alternative to parabens. The International Nomenclature of Cosmetic Ingredients name is Ethylhexylglycerin, and the chemical formula and synonym names are shown in Figure 1. Ethylhexylglycerin is a colorless to pale viscous liquid. It is reported to be used at a concentration up to 2% in leave-on products and 8% in rinse-off products. It is manufactured and marketed by Schu¨lke & Mayr GMBH, Norderstedt, Germany, under the trade name, Sensiva SC50, which is greater than 99% pure. Ethylhexylglycerin is found in many cosmetic products, that is, antiaging creams, sunscreens, eye shadows, eye creams, lip gloss, deodorants, facial moisturizers, and various types of cleansers.

Safety

With an EWG score of 1 and a rating of GOOD from Paula’s Choice, ethylhexylgylcerin is deemed to be very safe and a non-irritant.
Ethylhexylglycerin is a topical skin care ingredient and deodorizing agent, often indicated as a conditioning ointment in the treatment of eczema. It can also be a surfactant and preservative-enhancer and can be found as a substituent for parabens. Ethylhexylglycerin is commonly found in baby products or cosmetics marketed as “hypoallergenic” or “formaldehyde free”.
Ethylhexylglycerin has been reported to cause dermatitis and skin irritation.
www.cir-safety.org
What Is Ethylhexylglcerin & Is It Safe?

Toxicity evaluation

The oral toxicity of ethylhexylglycerin (Sensiva® SC 50, in polyethylene glycol 400) at doses of 100, 500, and 1,500 mg/kg was evaluated in a 28-day study using groups of 10 rats of an unspecified strain. The test substance was administered at a dose volume of 5 ml/kg.There were no treatment-related mortalities. Body weight development was retarded in mid- and high-dose groups, and this finding was accompanied by a non-statistically significant reduction in food intake when compared to the control (polyethylene glycol 400) group. Both eye and ear functions remained unchanged during the study, and increased salivation (dose not stated) was the only clinical symptom observed. Hematological parameters were unaffected by treatment; however, serum analyses indicated changes in aminotransferase (above normal) in high-dose rats. Urinalysis and necropsy findings were unremarkable.

Reference

W. Beilfuss, M. Leschke, K. Weber, A New Concept to Boost the Preservative Efficacy of Phenoxyethanol, SÖFW-Journal, 2005, vol. 131

Uses

Ethylhexylglycerin is the novel raw material for deodorants application and is widely used as a cosmetic emollient. Ethylhexylglycerin reliably inhibits the odor-causing bacteria, yeast and fungi on the skin.

Contact allergens

This glycerol monoalkylether is used as a skin conditioning agent, with bactericidal properties against Gram-positive bacteria.

Synthesis

Synthesis of ethylhexylglycerin is via the catalytic splitting of ethylhexylglycidyl ether followed by the addition of water. The product can then be purified by vacuum distillation.

Ethylhexylglycerin(70445-33-9)Related Product Information

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• 1-PROPOXY-2-PROPANOL
• DOWANOL(TM) PNB
• Allyl glycidyl ether
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• 1,2,3-PROPANETRIOL GLYCIDYL ETHER
• DIGLYCEROL
• ANTIFOAM PE-L
• 1-Methoxy-2-propyl acetate
• (2-Methoxyethyl)benzene
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• 1-Phenoxy-2-propanol