Propanolol Chemical Properties

Melting point:

163-164 °C

Boiling point:

402.6°C (rough estimate)

Density 

1.0280 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.84±0.20(Predicted)

color 

White to Off-White

Water Solubility 

80.99mg/L(25 ºC)

CAS DataBase Reference

525-66-6

NIST Chemistry Reference

Propranolol(525-66-6)

EPA Substance Registry System

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- (525-66-6)

MSDS

• Language:English Provider:1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol

Propanolol Usage And Synthesis

Description

Propranolol was responsible for sensitisation of workers in drug synthesis. In one case, epichlorhydrin was used for the production of both propranolol and oxprenolol.

Chemical Properties

Colorless crystals.Soluble in water and alcohol; insoluble in benzene and ether.

Uses

β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

Cardiac depressant (anti-arrhythmic); anti-adrenergic (β-receptor).

Definition

ChEBI: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Indications

Major indications of propranolol, and of many other β-blockers, include coronary heart disease, hypertension, and cardiac arrhythmias. These β-blocking agents are mainly used in arrhythmias accompanied by increased catecholamine levels, e.g., excitement, stress, or hyperthyroidism .

brand name

Inderal (Wyeth); Innopran (Reliant).

Hazard

Highly toxic.

Contact allergens

Propranolol is a beta-blocking agent that was responsible for the sensitization of workers in drug synthesis. In one case, epichlorhydrin was used for the production of drugs propranolol and oxprenolol. Crossreactivity is expected between beta-blockers.

Propanolol(525-66-6)Related Product Information

• 1-(2,6-Dimethylphenoxy)-2-propanamine
• 2-Propanol, 1-chloro-3-(1-naphthalenyloxy)-, (S)-
• 2-Propanol, 1-chloro-3-(1-naphthalenyloxy)-, (2R)-
• 1-chloro-3-(1-naphthyloxy)propan-2-ol
• Propranolol N-Acetyl Impurity
• RAC PROPANOLOL-D7
• Propranolol hydrochloride
• N-nitrosopropranolol
• Adimolol
• (S)-(-)-PROPRANOLOL HYDROCHLORIDE
• (R)-(+)-PROPRANOLOL
• Propanolol
• Naphthalene
• MEN 935
• PROPRANOLOL GLUCURONIDE SODIUM SALT
• DL-PROPRANOLOL-D7 (RING-D7)
• 5-Hydroxy Propranolol
• S-PROPRANOLOL