Basic information Safety Supplier Related

Letosteine

Basic information Safety Supplier Related

Letosteine Basic information

Product Name:
Letosteine
Synonyms:
  • 2-[2-(2-Ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid
  • 4-Thiazolidinecarboxylic acid, 2-[2-[(2-ethoxy-2-oxoethyl)thio]ethyl]-
  • Viscotiol
  • Visoctiol
  • 2-[2-[(2-Ethoxy-2-oxoethyl)thio]ethyl]-4-thiazolidinecarboxylic acid
  • Letosteine
  • 2-(2-((2-ethoxy-2-oxoethyl)thio)ethyl)thiazolidine-4-carboxylic acid
CAS:
53943-88-7
MF:
C10H17NO4S2
MW:
279.38
EINECS:
258-879-3
Product Categories:
  • API
Mol File:
53943-88-7.mol
More
Less

Letosteine Chemical Properties

Melting point:
142°
Boiling point:
470.0±45.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Dichloromethane (Slightly), DMSO (Slightly)
form 
Solid
pka
2.05±0.40(Predicted)
color 
White to Pale Yellow
CAS DataBase Reference
53943-88-7

MSDS

More
Less

Letosteine Usage And Synthesis

Originator

Viscotiol,Carlo Erba,France,1979

Definition

ChEBI: A dicarboxylic acid monoester that is the monoethyl ester of 2-{2-[(carboxymethyl)sulfanyl]ethyl}-1,3-thiazolidine-4-carboxylic acid. A mucolytic used in the treatment of chronic bronchopneumopathies and related conditions.

Manufacturing Process

In an Erlenmeyer flask placed in an ice bath, and under a well-ventilated hood, a solution of 0.1 mol of acrolein in 100 ml of ether was introduced, With the aid of a bromine ampoule, 0.1 mol (= 11 ml) of the ethyl ester of thioglycolic acid containing 0.5 ml of triethylamine was added drop by drop.
One hour after completion of the addition, there was added 0.1 mol (15.6 g) of chlorhydrate of cysteine in alcoholic solution. The chlorhydrate of the expected derivative, which appeared in the form of a thick oil, was precipitated by addition of 0.1 mol (10 g) of potassium acetate in aqueous solution. The abundant precipitate obtained was filtered and washed in water and ether. The product was recrystallized in a minimum of absolute alcohol.

Therapeutic Function

Mucolytic

LetosteineSupplier

TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Email
sales@RHFChem.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com