butetamate Chemical Properties

Boiling point:

bp11 167-169°

Density 

0.9903 (rough estimate)

refractive index 

nD20 1.4909

pka

9.22±0.25(Predicted)

butetamate Usage And Synthesis

Originator

Butetamat-dihydrogencitrat,Chemische Werke Hommel GmbH and Co.KG

Definition

ChEBI: Butetamate is an alkylbenzene.

Manufacturing Process

16.4 parts of alpha-phenylbutiric acid, 17.5 parts of beta-diethylaminoethylchloride hydrochloride and 35 parts of dry potassium carbonate in 60 parts diisopropyl ether was stirred for 18 hours under reflux. To the reaction mixture at 40°C was added 120 parts of the water. Organic layer was washed with the water. The solvent was removed and the 2- (diethylamino)ethyl-2-phenylbutyrate was distilled at 167-168°C/10 mm; melting point of hydrochloride 167-169°C.
In practice it is usually used as citrate.

Therapeutic Function

Anticholinergic, Spasmolytic, Antitussive

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