3-Amino-4-fluorophenol Chemical Properties

Melting point:

141-143 °C

Boiling point:

269.3±20.0 °C(Predicted)

Density 

1.347±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

10.03±0.18(Predicted)

form 

crystalline powder

color 

Light tan

InChI

InChI=1S/C6H6FNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2

InChIKey

VJCSFNNTQGRAKH-UHFFFAOYSA-N

SMILES

C1(O)=CC=C(F)C(N)=C1

CAS DataBase Reference

62257-16-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Hazard Note 

Toxic

HS Code 

2922290090

3-Amino-4-fluorophenol Usage And Synthesis

Description

3-amino-4-fluorophenol is a kind of organic chemistry intermediate commonly used as the intermediate for synthesizing compounds of liquid crystals, pharmaceutical compounds and agricultural chemical compounds used always.

Uses

3-Amino-4-fluorophenol is used to produce drugs with specific biological activities, including antibiotics and anti-inflammatory agents.

Synthesis

Add 450ml water in the 5L reaction flask, 708.5g (10.9mol) zinc powder, 303g (1.09mol) 2-bromo-4-fluoro-5-amino-benzene oxygen ethyl formate, mix, 45 ℃ drip the solution that 218g (5.45mol) sodium hydroxide and 1500ml water are made into down, insulated and stirred is warming up to 60 ℃ after 1 hour to be incubated 4 hours after reactions more complete, the cooling suction filtration, getting filtrate dropping 406g (3.33mol) 30% hydrochloric acid separates product, filtration obtains brown solid, use ethyl alcohol recrystallization, get yellow solid 118.5g (0.93mol) 3-amino-4-fluorophenol after the drying. A molar yield of 85% is 99.5% through gas chromatography determination purity.136 ℃/20mmHg of boiling point.

References

[1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 122 - 134
[2] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 38
[3] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 75-76
[4] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00253
[5] Patent: US2009/137595, 2009, A1

3-Amino-4-fluorophenol(62257-16-3)Related Product Information

• 6-Aminocaproic acid
• ALTRENOGEST
• 4-Aminophenol
• Acetaminophen
• 4-Fluorophenol
• Glycine
• 3-Aminophenol
• 2-Aminophenol
• Tris(hydroxymethyl)aminomethane
• 3-AMINO-2,6-DIMETHYLPYRIDINE
• FLUFENPYR-ETHYL
• FLUMICLORAC-PENTYL
• 4-Fluoro-3-nitrophenol
• o-Anisaldehyde
• PENTOXAZONE
• 2-Chloro-4-fluoro-5-nitrophenol
• 4-Amino-2-fluorophenol 98%,4-AMINO-2-FLUOROPHENOL,4-Amino-2-fluorophenol98%
• 4-AMINO-3-FLUOROPHENOL,4-Amino-3-Fluorophenol 3-Fluoro-4-Aminophenol,4-Amino-3-fluorophenol 98%,4-Amino-3-fluorophenol98%,4-AMINO-3-FLUOROPHENOL, 98% MIN.