4-Amino-1-benzylpiperidine Chemical Properties

Melting point:

121-122 °C(Solv: water (7732-18-5); ethanol (64-17-5))

Boiling point:

152 °C (9.7 mmHg)

Density 

0.933 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.543(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

10g/l

form 

Liquid

pka

10.15±0.20(Predicted)

color 

Clear colorless to light yellow

PH

11.4 (10g/l, H2O)

Water Solubility 

immiscible

Sensitive 

Air Sensitive

BRN 

146038

InChIKey

YUBDLZGUSSWQSS-UHFFFAOYSA-N

CAS DataBase Reference

50541-93-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36

Safety Statements 

26-36

WGK Germany 

3

F 

8-10-34

HazardClass 

IRRITANT

HS Code 

29333999

MSDS

• Language:English Provider:1-Benzylpiperidin-4-amine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Amino-1-benzylpiperidine Usage And Synthesis

Chemical Properties

clear colourless to light yellow liquid

Uses

4-Amino-1-benzylpiperidine was used in the preparation of:

• butyl 4-amino-1-piperidineacetate, key intermediate required for the synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate
• 5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one and 4-benzyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-isopropyl-1,2,4-thiadiazolidin-3-one
• glycyrrhetinic acid derivatives

Purification Methods

Purify it by distillation in vacuo and store it under N2 because it absorbs CO2. The dihydrochloride salt [1205-72-7] has m 270-273o (255o) after recrystallisation from MeOH/EtOAc or EtOH. [Brookes J Chem Soc 3165, 3172 1957.] The 4-methylamino-1-benzylpiperidine derivative has b 168-172o/17mm, nD 1.5367 [Reitsema & Hunter J Am Chem Soc 70 4009 1948]. The 1-(1-benzyl-4-piperidinyl)-3-cyano-2-methylisothiourea derivative has m 160o from CHCl3/Et2O [Preparation, IR, NMR: Ried et al. Chem Ber 116 1547 1983, Beilstein 22 III/IV 3752].

4-Amino-1-benzylpiperidine(50541-93-0)Related Product Information

• Haloperidol
• Benzyltriethylammonium chloride
• Glycine
• Triethanolamine
• Dibenzylamine
• Triallylamine
• 6-Aminocaproic acid
• Tris(hydroxymethyl)aminomethane
• ALTRENOGEST
• Bis(2-ethylhexyl)amine
• 1-Aminopiperidine
• N-Benzyl-4-piperidone
• Benzyl chloride
• DROPERIDOL
• 3-Aminophenol
• 4-Aminopiperidine
• Diphenoxylate
• (S)-3-AMINO-N-BENZYLPIPERIDINE,(S)-3-Amino-1-benzylpiperidine