Gepirone Chemical Properties

Melting point:

106-108°C

Boiling point:

562.3±60.0 °C(Predicted)

Density 

1.142±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

7.72±0.10(Predicted)

color 

Off-White to Pale Yellow

Gepirone Usage And Synthesis

Description

Gepirone is a chemical analogue of buspirone and also acts as a partial agonist at 5-HT1A receptors. It is active in animal models predictive of anxiolytic action and also shows antidepressant activity in preclinical studies. With long-term administration, gepirone downregulates 5-HT2 receptors, which is a property common to nearly all antidepressant drugs (Stahl 1994). This dual action, suggesting both anxiolytic and antidepressant effects, is typical of many compounds acting at 5-HT1A receptors and may indicate that such compounds may be useful in the treatment of mixed anxiety and depression (Stahl, in press).
Preliminary phase II clinical data have shown that gepirone is an effective anxiolytic that significantly reduces both psychic and somatic symptoms of generalized anxiety disorder. Like buspirone, gepirone does not impair memory, verbal fluency, or psychomotor performance (Harto and Branconnier 1988).

Uses

Gepirone is an antidepressant and anxiolytic of the azapirone class. It acts as a selective partial agonist of the 5-HT1A receptor.

Definition

ChEBI: Gepirone is a N-arylpiperazine.

Gepirone(83928-76-1)Related Product Information

• Pipemidic acid
• Azaperone
• Buspirone hydrochloride
• Gepirone
• BUSPIRONE (D8)
• Buspirone
• 6-HYDROXY BUSPIRONE