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ChemicalBook >  Product Catalog >  Organic Chemistry >  4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Basic information

Product Name:
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
Synonyms:
  • 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
  • 4-Chloro-6,7-(2-methoxyethoxy)quinazoline
  • 4-Chloro-6,7-bis(2-methoxyethoxy)quinazolin
  • 6,7-Bis(2-methoxyethoxy)-4-chloroquinazoline
  • Erlotinib Intermediate 1
  • 4-chloro-6,7-di(2-methoxyethoxy)quinazoline
  • CP-335963
  • PF-508367
CAS:
183322-18-1
MF:
C14H17ClN2O4
MW:
312.75
EINECS:
605-994-5
Product Categories:
  • API intermediates
  • Intermediate of erlotinib hydrochloride
  • intermidiate of Erlotinib hydrochloride
Mol File:
183322-18-1.mol
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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Properties

Melting point:
105-107 °C
Boiling point:
446.7±45.0 °C(Predicted)
Density 
1.257
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
0.54±0.30(Predicted)
color 
white to off-white
InChI
InChI=1S/C14H17ClN2O4/c1-18-3-5-20-12-7-10-11(16-9-17-14(10)15)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3
InChIKey
ZPJLDMNVDPGZIU-UHFFFAOYSA-N
SMILES
N1=C2C(C=C(OCCOC)C(OCCOC)=C2)=C(Cl)N=C1
CAS DataBase Reference
183322-18-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
2933599590
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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Usage And Synthesis

Uses

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is an aurora 2 kinase inhibitor, PDGF inhibitor, useful in the treatment of cancer.

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