Basic information Safety Supplier Related

D-BIOTIN P-NITROPHENYL ESTER

Basic information Safety Supplier Related

D-BIOTIN P-NITROPHENYL ESTER Basic information

Product Name:
D-BIOTIN P-NITROPHENYL ESTER
Synonyms:
  • PBNP
  • 4-NITROPHENYL (+)-BIOTINATE
  • (+)-BIOTIN 4-NITROPHENYL ESTER
  • BIOTIN P-NITROPHENYL ESTER
  • BIOTIN-ONP
  • BNP
  • D-BIOTIN P-NITROPHENYL ESTER
  • BNP d-Biotin p-nitrophenyl ester
CAS:
33755-53-2
MF:
C16H19N3O5S
MW:
365.4
EINECS:
1533716-785-6
Product Categories:
  • cytokine
Mol File:
33755-53-2.mol
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D-BIOTIN P-NITROPHENYL ESTER Chemical Properties

Melting point:
163-165 °C(lit.)
Boiling point:
642.9±50.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: soluble25mg/mL, clear, colorless to greenish-yellow
pka
13.89±0.40(Predicted)
form 
Solid
color 
White to Off-White
optical activity
[α]25/D +51°, c = 2 in DMF: AcOH (99:1)
BRN 
5795805
InChIKey
YUDNXDTXQPYKCA-OWYJLGKBSA-N
CAS DataBase Reference
33755-53-2
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
10-21
HS Code 
29349990

MSDS

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D-BIOTIN P-NITROPHENYL ESTER Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

(+)-Biotin 4-nitrophenyl ester may be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies. It may also be used to prepare biotinylated quinazoline derivatives, which shows inhibitory activities against VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinase. (+)-Biotin 4-nitrophenyl ester undergoes hydrolysis in the presence of Na[17O]H to form [17O2]biotin, which can be used in solid-state 17O NMR spectroscopic experiments to analyze large protein-ligand complexes.

Uses

For research use only. Not for use in diagnostic procedures.
Brain natriuretic peptide EIA Kit has been used to measure brain natriuretic peptide (BNP) secreted in human neonatal ventricular cardiomyocyte culture.

General Description

The BNP Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting BNP peptide based on the principle of Competitive Enzyme Immunoassay.

Biochem/physiol Actions

Brain natriuretic peptide (BNP) expressed in mammalian brain and atrial natriuretic peptide (ANP) facilitates various physiological functions including regulation of blood pressure and cardiac remodeling. BNP acts as a potential biomarker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular (LV) dysfunction. Elevated expression of BNP is observed in acute myocardial infarction (AMI) patients. BNP is also implicated in several biological functions such as diuresis, natriureis, hypotensive action and inhibition of aldosterone secretion.

Purification Methods

The ester has been recrystallised by dissolving 2g in 95% EtOH (30mL), heated to dissolve, then cooled in an ice-water bath. The crystals are collected, washed with ice-cold 95% EtOH (5mL) and dried over P2O5. The RF on silica plates (CHCl3/MeOH 19:1) is 0.19 [Bodanszky & Fagan J Am Chem Soc 99 235 1977].

D-BIOTIN P-NITROPHENYL ESTERSupplier

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