1-(3,4-Dimethylphenyl)piperazine Chemical Properties

Melting point:

60-65°C

Boiling point:

110 °C

Density 

1.0320 (rough estimate)

refractive index 

1.5540 (estimate)

Flash point:

175°C/10mm

pka

9.05±0.10(Predicted)

Sensitive 

Air Sensitive

BRN 

610230

CAS DataBase Reference

1014-05-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-R36/37/38-36

Safety Statements 

24/25-S24/25

RIDADR 

3259

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

II

HS Code 

29335995

MSDS

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1-(3,4-Dimethylphenyl)piperazine Usage And Synthesis

Chemical Properties

1-(3,4-Dimethylphenyl)piperazine is a light beige to faintly yellow crystalline powder,the enantioselectivity and yields are high when it is used in the ring-opening reaction with an aliphatic allylic amine. This reaction is also efficient with nucleophiles such as primary amines or alcohols.

Uses

1-(3,4-Dimethylphenyl)piperazine is a chiral building block for the synthesis of polysubstituted piperazines. It can be used as a bridgehead to synthesize asymmetric amines. 

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