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Solamargine

Basic information Safety Supplier Related

Solamargine Basic information

Product Name:
Solamargine
Synonyms:
  • SOLAMERGINE
  • Solamargine, >98%
  • Solamargine 20311-51-7
  • δ-Solanigrine
  • 2)-O-[6-deoxy-a-L-Mannopyranosyl-(1®
  • b-D-Glucopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-Mannopyranosyl-(1®
  • (3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside
  • [(22R,25R)-Spirosola-5-ene-3β-yl]2-O,4-O-bis(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
CAS:
20311-51-7
MF:
C45H73NO15
MW:
868.06
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids
Mol File:
20311-51-7.mol
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Solamargine Chemical Properties

Melting point:
301 °C
Density 
1.38
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12?+-.0.70(Predicted)
color 
Light Beige
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Solamargine Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the fruit of Solanum aviculare Forst.

Uses

α-Solamargine is a steroidal glycosyl-alkaloid which displays inactivation of PI3-L/Akt and reduction for SP1 and p65 in the suppression of human lung cancer cells.

Definition

ChEBI: Solamargine is an azaspiro compound, a steroid and an oxaspiro compound.

in vivo

Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo[4].

Animal Model:Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old)[4]
Dosage:10 mg/kg
Administration:Intragastric administration; once daily for 8 days
Result:Tumor growth was significantly inhibited .

SolamargineSupplier

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