6-Quinazolinecarboxylic acid (9CI) Chemical Properties

Boiling point:

359.5±17.0 °C(Predicted)

Density 

1.421±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.78±0.30(Predicted)

Appearance

Yellow to brown Solid

Safety Information

HS Code 

2933992000

6-Quinazolinecarboxylic acid (9CI) Usage And Synthesis

Uses

Quinazoline-7-carboxylic Acid is a derivative of Quinazoline (Q670100) which is used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. Quinazoline is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.

Synthesis

Ethyl quinazoline-6-carboxylate (79 mg, 0.391 mmol) was dissolved in ethanol (4 mL), 1 N aqueous sodium hydroxide (4 mL) was added, and the reaction was stirred for 1 h at room temperature. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 4 with 1 N hydrochloric acid, followed by vacuum evaporation to remove the solvent. Ethanol was added to the residue and the organic layer was concentrated. The residue was dissolved in ethyl acetate-tetrahydrofuran mixed solvent and dried with anhydrous magnesium sulfate followed by vacuum evaporation to give quinazoline-6-carboxylic acid (15 mg, 0.086 mmol, 22% yield). The resulting product was directly used in the subsequent reaction without further purification.1H-NMR (DMSO-d6) δ (ppm): 8.09 (1H, d, J = 8.8 Hz), 8.44 (1H, dd, J = 2.0, 8.8 Hz), 8.83 (1H, d, J = 2.0 Hz), 9.39 (1H, s), 9.79 (1H, s).

References

[1] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 58-59
[2] Patent: EP1669348, 2006, A1. Location in patent: Page/Page column 66-67

6-Quinazolinecarboxylic acid (9CI)(676326-53-7)Related Product Information

• Formic acid
• 6-Quinazolinamine (9CI)
• METHYL QUINOLINE-6-CARBOXYLATE
• QUINOXALINE-6-CARBALDEHYDE
• 5-QUINOXALINECARBONITRILE
• 2-Quinoxalinecarboxylic acid methyl ester
• QUINOXALINE-5-CARBOXYLIC ACID
• Methyl quinoxaline-5-carboxylate
• 6-Quinazolinecarboxaldehyde (9CI)
• 6-Quinoxalinemethanamine
• 8-Quinazolinol (6CI,7CI,8CI,9CI)
• Quinazoline-8-carbonitrile
• 5-Hydroxyquinoxaline
• QUINOXALINE-6-CARBOXYLIC ACID HYDRAZIDE
• Quinoxaline-6-acetic acid
• 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxaline
• Boronic acid, 6-quinoxalinyl- (9CI)
• (5-METHOXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID