2'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

CAS DataBase Reference

198205-79-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2916399090

2'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 2'-trifluoromethyl diphenyl-4-carboxylic acid from 2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde: The product of step A (0.4 g, 1.6 mmol) was refluxed for 2 h under stirring with a suspension formed by potassium permanganate (KMnO4, 0.502 g, 3.2 mmol) in dioxane (15 mL). After completion of the reaction, the mixture was filtered through a silica gel column and the filter cake was washed with ethyl acetate (EtOAc, 30 mL). Subsequently, the solvent in the filtrate was evaporated to dryness to afford the target product 2'-trifluoromethyl diphenyl-4-carboxylic acid (0.35 g, 81.6% yield) as a white solid. The 1H-NMR (CDCl3) data of the product were as follows: δ 7.30-7.58 (m, 5H); 7.76 (d, 1H, J = 8.15 Hz); 8.11 (d, 2H, J = 8.03 Hz).

References

[1] Patent: WO2010/42998, 2010, A1. Location in patent: Page/Page column 95
[2] Patent: WO2005/97740, 2005, A1. Location in patent: Page/Page column 28-29
[3] Patent: US2010/48580, 2010, A1. Location in patent: Page/Page column 11

2'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(198205-79-7)Related Product Information

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