ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE
ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Basic information
- Product Name:
- ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE
- Synonyms:
-
- ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE
- 2-[Bis(2,2,2-trifluoroethoxy)phosphinyl]propanoic Acid Ethyl Ester
- Ethyl 2-(2,2,2-Trifluoroethyl Phosphono)propionate
- Propanoic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester
- Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)propanoate
- CAS:
- 107905-52-2
- MF:
- C9H13F6O5P
- MW:
- 346.16
- Product Categories:
-
- Wittig Reagents
- Miscellaneous Reagents
- Mol File:
- 107905-52-2.mol
ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Chemical Properties
- Boiling point:
- 115-120°C/20mmHg
- Density
- 1.381±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Clear Colourless to Pale Yellow
- CAS DataBase Reference
- 107905-52-2
ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Usage And Synthesis
Chemical Properties
Colourless Liquid
Uses
A wittig reagent.
Uses
Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate is an organic synthesis reagent, mainly used in organic synthesis and chemical production.
Synthesis
KHMDS (7.50 mL, 3.75 mmol, 0.5 M in toluene) was added to a solution of 18- crown-6 (4.10 g, 15.51 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1) (0.50 mL, 3.41 mmol) by syringe in a dropwise manner at -78 ℃. Following 15 min, ethyl 2-bromopropionate (0.40 mL, 3.08 mmol) was added to the round bottom flask and the reaction mixture was allowed to stir for 4 hr at room temperature. Following the standard workup procedure, the crude product was then purified by flash column chromatography (3:1 to 2:1 hexanes:EtOAc, Rf = 0.33 in 1:1 hexanes:EtOAc) yielding Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate (112 mg, 0.33 mmol, 10.5%) as a yellow syrup.
ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATESupplier
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