2-AMINO-5-CHLOROBENZYL ALCOHOL Chemical Properties

Melting point:

107-109 °C(lit.)

Boiling point:

320.7±27.0 °C(Predicted)

Density 

1.341±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

13.94±0.10(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

37585-25-4

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

2-AMINO-5-CHLOROBENZYL ALCOHOL Usage And Synthesis

Synthesis

GENERAL PROCEDURE: A solution was prepared by dissolving 2-amino-5-chlorobenzoic acid (8.5 mmol) in THF (24 mL) at room temperature. This solution was added dropwise to a suspension of lithium aluminum hydride (20.4 mmol) in THF (10 mL) over 20 minutes. The reaction mixture was stirred continuously for 3.5 h at room temperature. Subsequently, water (10 mL) was added slowly at 0 °C to quench the reaction. The resulting suspension was filtered through a diatomaceous earth plug and washed with EtOAc (100 mL). The organic phase was washed with brine (30 mL), dried over anhydrous MgSO4 and finally concentrated under vacuum to give 2-amino-5-chlorobenzyl alcohol.

References

[1] ACS Catalysis, 2013, vol. 3, # 4, p. 622 - 624
[2] Organic Letters, 2017, vol. 19, # 12, p. 3219 - 3222
[3] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799
[4] Patent: WO2010/37533, 2010, A1. Location in patent: Page/Page column 44
[5] Organic Letters, 2016, vol. 18, # 21, p. 5572 - 5575

2-AMINO-5-CHLOROBENZYL ALCOHOL(37585-25-4)Related Product Information

• OXAZOLAM METHANOL SOLUTION
• 2-AMINO-5-CHLOROBENZYL ALCOHOL
• 6-CHLOROISATIN
• 5-CHLORO-2,4-DINITROBENZOIC ACID
• 5-CHLORO-2-NITROBENZYL ALCOHOL
• Methyl 5-chloroanthranilate
• 5-Chloro-2-nitrobenzoic acid
• Inabenfide
• 3,5-Dichloroanthranilic acid
• 2-Amino-5-chlorobenzoic acid
• 6-chloro-1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione
• METHYL 2-ACETAMIDO-5-CHLOROBENZOATE
• 5-CHLORO-2-[(CHLOROACETYL)AMINO]BENZOIC ACID
• 3,5-DICHLOROISATOIC ANHYDRIDE
• 2-AMINO-5-CHLOROBENZYL ALCOHOL
• 2-(BUTYLAMINO)-6-CHLORO-4H-BENZO[D][1,3]OXAZIN-4-ONE
• 2-AMINO-5-CHLOROBENZOIC ACID [CARBOXYL-14C]
• 5-CHLORO-2-PHENYLAMINO-BENZOIC ACID